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賴德仁 教授




 賴德仁 校長/教授

Te-Jen Lai, MD, PhD




中山醫學大學醫學系精神學科 主任 

中山醫學大學醫學研究所、醫學系 教授

中山醫學大學附設醫院精神科 主治醫師

台灣精神醫學會 理事長

台灣失智症協會 理事長





成大醫院精神科 住院醫師、主治醫師、講師

中山醫學大學醫學系 講師、副教授

中山醫學大學醫學系精神科 主任

中山醫學大學職能治療學系 主任

中山醫學大學醫學系家庭暨社區醫學科 主任

中山醫學大學醫學系 副主任、主任

中山醫學大學醫學研究所 所長

中山醫學大學附設醫院精神科 主任

中山醫學大學附設復健醫院 院長

中山醫學大學  校長 

美國杜克大學老年精神科 (Duke University Medical Center) 訪問學者

臺灣憂鬱症防治協會 理事長 

台灣老年精神醫學會 理事長



期刊論文(since 2012) (*Corresponding author)


  1.Lin TY, Chen VC, Lee CH, Chen CY, Shao WC, Chang SH, Chou JY, Lai TJ, Ferri CP, GossopM, Lee CT. Prevalence, correlates, and risk perception of HIV infection among heroin users in  Central Taiwan. Kaohsiung J Med Sci. 2013Dec;29(12):673-9(SCI)IF: 0.805; Ranking: 101/122: 82.79 %

2.Teng PR, Yeh CJ, Lee MC, Lin HS, Lai TJ*. Change in depressive status and mortality in elderly persons: Results of a national longitudinal study. Arch Gerontol Geriatr. 2013Jan-Feb;56(1):244-9.(SCI)IF: 1.525; Ranking: 31/49: 63.27 %

3.Liu SY, Liu TC, Teng YL, Lee LA, Lai TJ*, Wu CM. Environmental sounds recognition in children with cochlear implants. PLoS One. 2013 Jun 20;8(6)(SCI)IF: 3.534; Ranking: 8/55: 14.55 %

4.Chang CC, Lai TJ*. Variability of waist circumference and its relationship with cardiovascular risk factors in outpatients with schizophrenia. Psychiatry Res. 2013 Jul 30;208(2):191-193. (SCI)IF: 2.682; Ranking: 56/135: 41.48 %

5.Teng PR, Lai TJ*. Paliperidone-related Pisa syndrome. J Clin Psychopharmacol. 2013 Feb;33(1):129-131. (SCI)IF:3.761; Ranking: 47/254: 18.50 %

6.Teng PR, Yeh CJ, Lee MC, Lin HS, Lai TJ*. Depressive symptoms as an independent risk factor for mortality in elderly persons: results of a national longitudinal study. Aging Ment Health. 2013;17(4):470-478.(SCI)IF: 1.781; Ranking: 28/49 : 57.14 %

7.Tsai LY, Huang CY, Liao WC, Tseng TH, Lai TJ*. Assessing student nurses' learning needs for addressing patients' sexual health concerns in Taiwan. Nurse Education Today 2013 Feb;33(2):152-159.(SCI) IF: 1.456; Ranking: 24/106: 22.64 %

8.Chiu YW, Chao PY, Tsai CC, Chiou HL, Liu YC, Hung CC, Shih HC, Lai TJ, Liu JY. Ocimum gratissimum is Effective in Prevention against Liver Fibrosis in Vivo and in Vitro. Am J Chin Med. 2014;42(4):833-52. (SCI)IF: 2.625; Ranking: 3/22: 13.63 %

9.Chen CH, Lee CS, Lee MT, Ouyang WC, Chen CC, Chong MY, Wu JY, Tan HK, Lee YC, Chuo LJ, Chiu NY, Tsang HY, Chang TJ, Lung FW, Chiu CH, Chang CH, Chen YS, Hou YM, Chen CC, Lai TJ, Tung CL, Chen CY, Lane HY, Su TP, Feng J, Lin JJ, Chang CJ, Teng PR, Liu CY, Chen CK, Liu IC, Chen JJ, Lu T, Fan CC, Wu CK, Li CF, Wang KH, Wu LS, Peng HL, Chang CP, Lu LS, Chen YT, Cheng AT; Taiwan Bipolar Consortium. Variant GADL1 and response to lithium therapy in bipolar I disorder. N Engl J Med. 2014 Jan 9;370(2):119-28. (SCI)IF:54.420; Ranking: 1/150: 0.66 %

10.Chang CC, Wang WF, Lai TJ*. Possible paliperidone-related pons infarction. J Neuropsychiatry Clin Neurosci. 2014 January;26(1):E15-6. (SCI)IF: 2.765; Ranking: 72/194: 37.11 %

11.Ju PC, Chou FH, Lai TJ, Chuang PY, Lin YJ, Yang CW, Tang CH. Long-Acting Injectables and Risk for Rehospitalization Among Patients with Schizophrenia in the Home Care Program in Taiwan. J Clin Psychopharmacol. 2014 Feb;34(1):23-9.IF:3.761; Ranking: 47/254: 18.50 %

12.Ho SC, Hsu CC, Pawlak CR, Tikhonova MA, Lai TJ, Amstislavskaya TG, Ho YJ. Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model. Behav Brain Res. 2014 Jul 15;268:177-84.(SCI)IF:3.391; Ranking: 14/49: 28.57 %

13.Lin TC, Lee CT, Lai TJ, Lee CT, Lee KY, Chen VC, Stewart R. Association of asthma and bipolar disorder: A nationwide population-based study in Taiwan. J Affect Disord. 2014 Jul 2;168C:30-36. (SCI)IF:3.705; Ranking: 39/194: 20.10 %

14.Chang CC, Jou SH, Lin TT, Lai TJ*, Liu CS. Mitochondria DNA change and oxidative damage in clinically stable patients with major depressive disorder. PLoS One. 2015 May 6;10(5) (SCI) IF:3.234; Ranking: 9/57: 15.79 %

15.Hsin-Hua Li, Fung-Jou Lu, Hui-Chih Hung, Guang-Yaw Liu, Te-Jen Lai* and Chih-Li Lin*. Humic acid increases amyloid β-induced cytotoxicity by induction of ER stress in human SK-N-MC neuronal cells. Int J Mol Sci. 2015 May 7;16(5):10426-10442. (SCI) IF:2.862; Ranking: 157/46: 26.23 %

16.Shih FF, Chen CH, Chiao CY, Li CR, Kuo PC, Lai TJ*. Comparison of pregnancy stress between in vitro fertilization/embryo transfer and spontaneous pregnancy in women during early pregnancy. J Nurs Res. 2015 Jun 30. (SCI) IF:0.970; Ranking: 54/109: 49.54 %

17.Chen VC, Kuo CJ, Wang TN, Lee WC, Chen WJ, Ferri CP, Tsai D, Lai TJ, Huang MC, Stewart R, Ko YC. Suicide and other-cause mortality after early exposure to smoking and second hand smoking: A 12-Year population-based follow-up study. PLoS One. 2015 Jul 29;10(7) (SCI) IF:3.234; Ranking: 9/57: 15.79 %

18.Huang CK, Chang YT, Amstislavskaya TG, Tikhonova MA, Lin CL, Hung CS, Lai TJ*, Ho YJ*. Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson's disease dementia. Behav Brain Res. 2015 Nov 1;294:198-207. (SCI) IF:3.028; Ranking: 18/51: 35.29 %

19.Su-ChungYoun, Li-You Chen, Ruei-Jen Chiou, Te-Jen Lai, Wen-Chieh Liao, Fu-Der Mai, Hung-Ming Chang*. Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency. Sci Rep. 2015 Dec 17;5:18420. (SCI) IF:5.578; Ranking: 5/57: 8.77 %

20.Chen VC, Liao YT, Lai TJ, Lane HY, Shao WC, Dewey M, Lee CT, Lu ML. Survival analysis of the use of first and second generation antipsychotics among patients suffering schizophrenia: A nationwide population-based cohort study. Schizophr Res. 2015 Dec;169(1-3):406-411. (SCI) IF3.923; Ranking: 30/140: 21.43 %

21.Chiu PY, Tsai CT, Chen PK, MD, Liu YL, MD, Lai TJ*. Frequency of Early and Late-onset Dementias in a Taiwanese Dementia Clinic: First Report on the Lin-Shin Dementia Registry Project. Taiwanese J Psychiatry 2015; 29:29-39.

22.Cummings J, Lai TJ, Hemrungrojn S, Mohandas E, Yun Kim S, Nair G, Dash A Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies. CNS Neurosci Ther. 2016 Jan 18. (SCI) IF3.931; Ranking: 68/252: 26.98 %

23.Zhao QF, Tan L, Wang HF, Jiang T, Tan MS, Tan L, Xu W, Li JQ, Wang J, Lai TJ, Yu JT. The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis. J Affect Disord. 2016 Jan 15;190:264-71. (SCI) IF3.383; Ranking:47/252:18.65 %

24.Lin CL, Cheng YS, Li HH, Chiu PY, Chang YT, Ho YJ, Lai TJ*. Amyloid-β suppresses AMP-activated protein kinase (AMPK) signaling and contributes to α-synuclein-induced cytotoxicity. Exp Neurol. 2016 Jan;275 Pt 1:84-98. (SCI) IF4.696; Ranking: 51/192: 26.56 %

25.Chang CC, Lee CT, Lan TH, Ju PC, Hsieh YH, Lai TJ*. Effects of antidepressant treatment on total antioxidant capacity and free radical levels in patients with major depressive disorder. Psychiatry Research, 2015 Dec 230:575-580. (SCI) IF2.467; Ranking: 61/140: 43.57 %.

26.Li HH, Lin SL, Huang CN, Lu FJ, Chiu PY, Huang WN, Lai TJ*, Lin CL. miR-302 Attenuates Amyloid-β-Induced Neurotoxicity through Activation of Akt Signaling. J Alzheimers Dis. 2016 Feb 5;50(4):1083-1098 (SCI) IF:3.731, Ranking: 77/258; 29.8%

27.Chiu PY, Tsai CT, MS, Chen PK, MD, Chen WJ, MS, Lai TJ*. Neuropsychiatric symptoms in Parkinson’s disease dementia are more similar to Alzheimer’s disease than dementia with Lewy bodies: a case-control study. PLOS ONE 2016 Apr 11(4):e0153989.(SCI) IF:3.234; Ranking: 9/57: 15.79 %.

28.Chao PY, Lin JA, Ting WJ, Lee HH, Hsieh K, Chiu YW, Lai TJ, Hwang JM, Liu JR, Huang CY. Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters. Int J Med Sci. 2016 Oct 18;13(11):819-824. (SCI) IF:2.399; Ranking: 36/155: 23.22 %.

29.Chao PY, Chiang TI, Chang IC, Tsai FL, Lee HH, Hsieh K, Chiu YW, Lai TJ, Liu JY, Hsu LS, Shih YC. Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum. Int J Med Sci. 2017 Jul 20;14(9):896-901. (SCI) IF:2.399; Ranking: 36/155: 23.22 %.

30.Chiang TI, Chang IC, Lee HH, Hsieh KH, Chiu YW, Lai TJ, Liu JY, Hsu LS, Kao SH. Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate. Int J Med Sci. 2016 Oct 19;13(11):853-857. (SCI) IF:2.399; Ranking: 36/155: 23.22 %.

31.Chiu PY, Wang CW, Tsai CT, Li HH, Lin CL, Lai TJ*. Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease. PLoS One. 12:e0179399, 2017. (SCI) IF:3.234; Ranking: 9/57: 15.79 %.

32.Chang CC, Li HH, Chang YT, Ho YJ, Hsieh JL, Chiu PY, Cheng YS, Lin CL, Lai TJ*. Aβ exacerbates α-synuclein-induced neurotoxicity through impaired insulin signaling in α-synuclein-overexpressed human SK-N-MC neuronal cells. CNS Neurosci. Ther.24:47-57, 2018. (SCI) IF: 3.919,Ranking : 47/256 : 18.4%.

33.Ho YJ, Weng JC, Lin CL, Shen MS, Li HH, Liao WC, Tsai NM, Chiu PY, Hung CS, Lai TJ*. Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies. Behavioural and Cognitive Changes in Lewy Body Dementias. (Accepted).(SCI)


1.Chiu PY, Lai TJ*. 2013, Rivastigmine patch in the one-year treatment of mild to moderate Alzheimer's disease and Parkinson’s disease dementia. The 16th International Psychogeriatric Association International Congress. IPA, Seoul, Korea.

2.Chiu PY, Lai TJ*. 2013, Performance on the Frontal Assessment Battery Test in Dementia with Lewy Bodies and Alzheimer’s Disease. The 11th Alzheimer’s and Parkinson’s Disease Conference AD/PD, Florence, Italy.

3.Lai TJ, Chiu PY, Lin JH. 2013, Hallucinations in Subcortical Vascular Dementia. The 8 th Annual Meeting of the Taiwanese Society of Geriatric Psychiatry, Taichung, Taiwan..

4.Pai-Yi Chiu, Te-Jen Lai*. 2014, Psychosis in Normal Pressure Hydrocephalus. The 9 th Annual Meeting of the Taiwanese Society of Geriatric Psychiatry, Taichung, Taiwan.

5.Yu-Shih Cheng,Hsin-Hua Li, Pai-Yi Chiu, Hsiu-Han Chang, Chih-Li Lin, Te-Jen Lai*. 2014, α-Synuclein, Amyloid β and Autophagy Inhibition in Dementia with Lewy bodies. The 9 th Annual Meeting of the Taiwanese Society of Geriatric Psychiatry, Taichung, Taiwan.

6.Pai-Yi Chiu, Te-Jen Lai, Depression in Normal Pressure Hydrocephalus. 2015, The 10 th Annual Meeting of the Taiwanese Society of Geriatric Psychiatry, Taichung, Taiwan.

7.Te-Jen Lai, Yen-Ting Chang, Shan-Ko Tsai, Hea Gyum Kim, Yu-Jou Tsai, Hsin-Hua Li, Wen-Nung Huang, Ying-Jui Ho, Chih-Li Lin, Molecular interplay between Aβ and mTOR signaling in α-synuclein-induced cognitive decline. 2015, The 10th Annual Meeting of the Taiwanese Society of Geriatric Psychiatry, Taichung, Taiwan.

8.Te-Jen Lai, Hsin-Hua Li, Chih-Li Lin, Pai-Yi Chiu. 2016, Synergistic Effects of Aβ on α-Synuclein-induced Neurotoxicity and Behavioral Deficits in Dementia with Lewy Bodies (DLB). International Congress, International Psychogeriatric Association, San Francisco, U.S.A.

9.Chiu PY, Wei CY, Lai TJ. 2016, The revised consensus criteria for the clinical diagnosis of dementia with Lewy bodies includes milder patients: compared with the original criteria. 2016 IPA Asian Regional Meeting, Taipei, Taiwan.

10.Chiu PY, Lai TJ. 2016, Parkinson’s disease dementia: determined with National Institute of Mental Health Provisional Criteria. The 11th International Congress on Non-Motor Dysfunction in Parkinson’s Disease and Related Disorders, Ljubljana, Slovenia.

11.Lin CL, Li HH, Chang CC, Ho YJ, Chiu PY, Hsieh CL, Lai TJ. 2016. Investigating molecular mechanisms of Aβ and α-synuclein synergistic effects of neurotoxicity and behavioral deficits in dementia with Lewy Bodies. 2016 International Psychogeriatric Association Asian Regional Meeting, Taipei, Taiwan.

12. Lai TJ, Lin CL, Li HH, Chiu PY, Ho YJ. 2017. Dysregulation of insulin signaling plays an important role in dementia with Lewy bodies (DLB). Belyaev conference 2017, Russian Academy of Sciences, Novosibirsk, Russia.

13. Li HH, Lu FJ, Chiu PY, Ho YJ, Lai TJ, Lin CL. 2017. Overexpression of Nanog Attenuates Aβ-induced Neurotoxicity through Insulin Signaling. Belyaev conference 2017, Russian Academy of Sciences, Novosibirsk, Russia.

14.Lin CL, Li HH, Kim HG, Chang CC, Chiu PY, Ho YJ, Lai TJ. 2017. Coexpression of Oct4, Sox2, Klf4 and Nanog (KOSN) transcription factors protects against amyloid β-induced neurotoxicity by improving insulin signaling sensitivity . Belyaev conference 2017 , Russian Academy of Sciences, Novosibirsk, Russia