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分類清單
基礎科副系主任

 

 

醫學系副系主任:李怡靜 教授

學歷 

中山醫學大學醫學研究所博士

 

經歷

中山醫學大學醫學系副系主任

 

中山醫學大學藥理科主任

專長

藥理學

毒理學

研究

口腔材料毒性的探討
環境重金屬對細胞的影響
先天性心臟結構異常與體內生長因子的相關性

論文

發表

1. LEE, C. H., LIN, S. J., NG, H. K., WU, L. J., and LIN, R. H. (1992)A comparison of improvement in motor performance under 4-aminopyridine and other antidotes in chlormazine pretreatment mice.J.Clin.Pharmacy Assoc.1(1),59-66.

2. LEE, C.H., NG, H. K., WU, L. J., CHIANG, P.Y., and LIN,R.H.(1992)Effects of 4-aminopyridine on chlorpromazine-induce decrement of muscle performance in mice.Chung Shan Med.J.,3(1), 18-26.

3. LIN,R.H.,WU, L..J., LEE, C.H., and LIN-SHIAU, S.Y.(1993)Cytogenetic toxicity of uranyl nitrate in Chinese hamster ovary cells. Mutat. Res.,319,197-203.(NSC-80-0421-B040-03Z).(SCI)

4. LIN, R.H., LEE,C.H.,CHEN, W.K., and LIN-SHIAU, S.Y.(1994)Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in Chinese ovary cells.Environ. and Mol. Mutagen. 23,143-149.(NSC-80-0421-B040-03Z).(SCI)

5. LEE, C.H.,LIN,R.H.,LIU,S.H. and LIN-SHIAU,S.Y.(1996) :Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells.Mutation Res. 367; 99 - 104.(NSC 81-0412-B-040-504) (SCI)

6. LEE,C.H., LIN, R. H., LIU, S.H., and LIN-SHIAU,S.Y. (1996)Search for antidotes of phenylmercury acteate-induced genotoxicity in cultured human lymphocytes. Environ. and Mol. Mutagen, Submitted.(NSC 83-0421-B-040-010-Z).(SCI)

7. LEE, C. H., LIN,R.H., LIU, S.H., and LIN-SHIAU, S.Y.(1997)Distinct genotoxicity of phenylmercury acetate in human lymphocytes as compared with other mercury compounds. Mutution Res., Submitted. (NSC 83-0421-B-040-010-Z).(SCI)

8. LEE,C.H., LIN, R. H., LIU, S.H., and LIN-SHIAU,S.Y. (1997)Search for antidotes of phenylmercury acteate-induced genotoxicity in cultured human lymphocytes. Environ. and Mol. Mutagen, revised.(NSC 83-0421-B-040-010-Z).(SCI)

9. LEE, C.H., LIN, R.H., LIU, S.H., and LIN-SHIAU, S.Y.(1998)Effects of germanium oxide and other chemical compounds on phenylmercury acetate-induced genotoxicity in cultured human lymphocytes. Environ. Mol. Mutagen., 31, 157-162.(NSC 83-0421-B-040-010-Z).(SCI)

10. Fong-Lin Chen, Yi-Ching Li, Po-Yen Liu, Chih-Yuan Weng, Chung-Pin Liao, Ju-Yu Liao Chung Shan Medical Journal 14(1): 145-150, 2003:Prenatal Diagnosis of Double Aortic Arch

11. Fong L. Chen, M.D.,Ming C. Hsiung, M.D., Kai S. Hsieh, M.D., Ph.D., Yi C. Li, M.D., and Ming C. Chou, M.D., Ph.D.ECHOCARDIOGRAPHY,Volume 23, October 2006: Real Time Three-Dimensional Transthoracic Echocardiography for Guiding Amplatzer Septal Occluder Device Deployment in Patients with Atrial Septal Defect.

12. Li YC,Huang FM, Lee SS, Lin RH, Chang YC J Biomed Mater Res B Appl Biomater. 2006 Oct 13; [Epub ahead of print]:Protective effects of antioxidants on micronuclei induced by camphorquinone/N,N-dimethyl-p-toluidine employing in vitro mammalian test system..

13. Li YC,Huang FM, Lee SS, Lin RH, Chang YC J Biomed Mater Res B Appl Biomater. 2007 Mar 06; [Epub ahead of print]:Protective effects of antioxidants on micronuclei induced by irradiated/N,N-dimethyl-p-toluidine in CHO cells

 

研討

會論

 

1. LIN, R.H., LEE, C.H., WU, L.J. and LIN-SHIAU,(1992)Cytogenotoxic effects of heavy metals in Chinese hamster ovary cells. The Third Annual Conference of Clinical Pharmacy Association., 19, Taichung .

2. LEE, C.H., NG, H.K., WU, L.J., CHIANG, P.Y.,and LIN.R.H. (1992)Improvement motor performance of 4 -aminopyridine in chlorpromazine pretreatment mice. The Third Annual Conference of the Clinical Pharmacy Association., 20 , Taichung .

3. LIN, R. H. , LEE, C. H. , LIN, S. J. , NG, H. K. , and WU, L. J .,(1992)Interactions between chlorpromazine and antidotes on motor performance and behaviors in mice. The Third Annual Conference of the Clinical Pharmacy Association, 21 Taichung .

4. LIN, R.H., WU, L.J., LEE, C.H., and LIN-SHIAU, S.Y.(1992)Cytotoxicity and genotoxicity of uranyl nitrate in CHO cells. The Seventh Joint Annual Conference of Biomedical Sciences. 121. Taipei . (NSC-80-0421-BO40-03Z)

5. LEE, C.H., WU, L.J., LIN, R.H., and LIN-SHAIU, S.Y. (1993)Mutagenic study of 4-aminopyridine by cytokinesis - block method in cultured Chinese hamster cells. The Eighth Joint Annual Conference of Biomedical Sciences,398, Taipei.(NSC-82-0115-CO40-01-007B)

6. LIN, R.H., CHIANG, C.K., LEE, C.H., andWU, L.J. (1993)Effects of cadmium nitrate on locomotor behavior in mice. The Eight Joint Annual Conference of Biomedical Sciences, 399, Taipei . (NSC-82-0115-CO40-01-008B)

7. LIN, R.H., WU, L.J., LEE, C.H., and LIN-SHAIU, S.Y. (1993)Cytogenotoxic studies of cadmium and lead in cultured Chinese hamster cells. The Eight Joint Annual Conference of Biomedical Sciences 400, Taipei . (NSC-800421-BO40-03Z)

8. LIN, R.H., CHIANG, J.G., SHY, S.W., and LEE, C.H., (1993)Effect of Subchronically adminstered cadmium nitrate on locomotor behaviors and health in mice. Second Interna-tional Conference of The Biogeochemistry of Trace Elements , 60, Taipei . (NSC-82-0115-CO40-01-08B)

9. LEE, C.H., LIN, R.H., WU, L.J., and LIN-SHIAU, S.Y. (1993)Elevated frequency of micronucleated cells by arecoline, cupric chloride, Sodium fluoride in Chinese hamster cells and their antidotes. International Conference of The Biogeochemistry of Trace Elememts, 44, Taipei . (NSC-81-0421-BO40-504)

10. LIN, R.H., HSU, I.C., CHIANG, J.G., LIN, S.J. and LEE,C.H. (1994)Toxicities of Single Subcataneous injection of cadmium nitrate in male adult mice. The Ninth Joint Annual Conference of Biomedical Sciences, 435, Taipei . (NSC-842815-CO40-01-001B)

11. LEE, C. H. , WU, L. J. , LIN, M. S. , CHEN, L. P. and LIN, R. H.(1994)Mutagenic study of 4-aminopyridine in CHO cells by using sister chromatid exchange assay, The Ninth Joint Annual Conference of Biomedical Sciences,441, Taipei.

12. LEE, C.H., LIN, R.H,, LIN, F. and LIN-SHIAU, S.Y. (1994)Genotoxicity of inorganic and organic compounds in cultured human lymphocytes. The 5th world congress of The World Federation of Associations of Clinical Toxicology Centers and Poison Control Centers , E00019. Taipei . (NSC-83-0421B040-01OZ)

13. Lin. R. H., LEE, C. H., WU, L.J. and LIN-SHIAU,S.Y.(1995); Study on genotoxic effects of mercury compounds and chelating agents in cultured human lymphocytes, The Joint Annual Conference of Biomedical Science,389,Taipei.

14. LIN.R.H.,LEE,C.H.,WU,L.J.and LIN-SHIAU,S.Y. (1995): Study on the effects of aminipyridine on neuromuscular transmission of the mouse diaphragm and genotoxicity in Chinese hamster lung cells. The Tenth Joint Annual Conference of Biomedical Science, 390, Taipei.(NSC-83-0421-B-040-01OZ)

15. Lee, C. H., Liu, C. S., Loa, C. L., Lin, R. H., Lin-Shiau, S. Y. (1996)Antagonistic effects of germanium oxide, d-penicillamine, and dimercaprol on genotoxicity induced by phenylmercury acetate in cultured human lymphocytes. The Eleventh Joint Annual Conference of Biomedical Science, P142, Taipei .

16. Lee, C.H., Chang, H.M., Lin, R.H. and Lin-Shian S.Y.(1997):Distinct genotoxicity of phenylmercury acetate in human lymphocytes as compared with other mercury compounds. The Twelfth Joint Annual Conference of Biomedial Sciences.232, Tapei.

7. Phan, W.L., Phoon, L.Y., Lee,C.H. and Lin, R.H. (1997):Studies on the motor behavioral effects of phenylmercury acetate in mice. The Twelfth Joint Annual Conference of Biomedical Sciences, 233, Taipei .

8. Lee, C.H., Lin,R.H., Liu,S.H. and Lin-Shian S.Y. (1997): Evaluation of antidotes on genotoxicity induced by phenylmercury acetate in cultured human lymphecytes. Fourth International conference on the Biogeochemixtry of Trace Elements.293-294, California .

9. CHANG, H.M ,.LEE, C.H., LIU, S.H., LIN, R.H and LIN-SHIAU, S.Y.(1998) Study on genotoxic effects of semiconductor metals in cultured mammalian cells, The Thirteenth Joint Annual Conference of Biomedial Sciences, p163, Tapei.

10. PHOON, L.Y., LEE, C.H. ,CHANG, H.M and LIN, R.H.(1998)A comparison of cytotoxicity of semiconductor metals on chinese hamster V79 lung cells, The Thirteenth Joint Annual Conference of Biomedial Sciences, p164, Tapei.

11. CHEN, F.L., CHANG, S.L., KUO, W.W., LIU, J.Y., HSIH, Y.S., WANG, C.J., LEE, C.H., HUANG, C.Y(2001).: Novel serum prognostic factors for ventricular septal defect children in Taiwan, The sixteenth Joint Annual Conference of Biomedial Sciences, p102, Tapei.

12. LEE, C.H., KUO, W.W., LIU, J.Y., HSIH, Y.S., WANG, C.J., CHEN, F.L., HUANG, C.Y (2001) : Antisense oligodeoxynucleotide targeted to insulin-like growth factors I and II as a novel strategy to investigate cardiac hypertrophy, The sixteenth Joint Annual Conference of Biomedial Sciences, p126, Tapei.

13. CHEN, F.L., CHANG, S.L., WU, J.P., KUO, W.W., LIU, J.Y., HSIH, Y.S., WANG, C.J., LEE, C.H., HUANG, C.Y(2001).: Novel serum prognostic factors for the ventricular septal defect children, XXXIV International Congress of Physiological Sciences, New Zealand

14. Fong-Lin Chen, Po-Yen Liu, Chung-Pin Liao, Yi-Ching Li, Chih-Yuan Weng, Ju-Yu Liao: Echocardiographic Screening For Cardiovascular Diseases among School Children in Taichung County, Taiwan: The 11th Asian Congress of Pediatrics and The 1st Asian Congress on Pediatric Nursing 2003.

15. Fong-Lin Chen, Po-Yen Liu, Chung-Pin Liao, Yi-Ching Li, Chih-Yuan Weng, Ju-Yu Liao: How Frequency of Undiagnosed Vascular Ring among School Children did it Occur? The 11th Asian Congress of Pediatrics and The 1st Asian Congress on Pediatric Nursing 2003.

16. Po-Yen Liu, Fong-Lin Chen, Yi-Ching Li, Chung-Pin Liao, Chih-Yuan Weng, Ju-Yu Liao, Da-Min Yeh, Kai-Sheng Hsieh, Ming-Chih Chou: Spiral Computed Tomography with Three-Dimensional Reconstruction for Evaluating Tracheal Compression in Children with Vascular Ring and Pulmonary Artery SL: 中華民國心臟學會第三十四屆年會暨學術演講會2004.

17. Fong-Lin Chen, Yi-Ching Li, Chung-Pin Liao, Chih-Yuan Weng, Ju-Yu Liao, Po-Yen Liu, Kai-Sheng Hsieh, Ming-Chih Chou: Diagnosis of Congenital Vascular Anomalies by Three-Dimensional Transthoracic Echocardiography with Color Doppler Flow Mapping: 中華民國心臟學會第三十四屆年會暨學術演講會2004.

18. Fong-Lin Chen, Zen-Chung Wen, Po-Yen Liu, Yi-Ching Li, Chung-Pin Liao, Chih-Yuan Weng, Ju-Yu Liao, Yu-Hung Chien, Jia-Yuh Chen, Ming-Chih Chou: Prevalence and Clinical Spectrum of Congenital Structural Heart Disease in School-Aged Children: A Echocardiographic Screening: The Scientific Committee of the 3rd International Congress on Cardiovascular Disease 2004.

19. Fong-Lin Chen, Zen-Chung Wen, Po-Yen Liu, Yi-Ching Li, Chung-Pin Liao, Chih-Yuan Weng, Ju-Yu Liao, Yu-Hung Chien, Jia-Yuh Chen, Ming-Chih Chou: Three-Dimensional Echocardiographic Display of Vascular Rings: The Scientific Committee of the 3rd International Congress on Cardiovascular Disease 2004.

20. Fong-Lin Chen, Shiang-Suo Huang, Yi-Ching Li, Jung-Min Yu, Yeu-Sheng Tyan, Si-Wa Chen, Kuo-Shuen Chen, Ming-Cheng Lin, Long-Yau Lin, Ming-Chih Chou, Shuping Ge: Congenital Vascular Rings and Slings are a Significantly Under-diagnosed Cause of Childhood Disease: Screening of 186,213 School-aged Children by Echocardiography. 56th Annual Scientific Session + Innovation in Intervention 2007.

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