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分類清單
余青翰老師
姓名   余青翰 (Ching-Han Yu)
職稱   助理教授
實驗室 實驗大樓四樓生理科
電話      (04) 2473-0022 ext.11655
傳真      (04) 2473-0022 ext.11655
信箱      chyu@csmu.edu.tw

  

1. 簡介

現任:中山醫學大學生理科    助理教授 (2010.02 ~)
學歷:陽明大學生理所        博士 (2008)
經歷:國立臺北護理健康大學  兼任助理教授 (2012.02~2013.06)

      靜宜大學              兼任助理教授 (2011.09~2012.01)

      陽明大學生理所        博士後研究員 (2008.09 ~ 2010.02)

      耕莘健康管理專科學校  兼任助理教授 (2009.09 ~ 2010.01)
研究興趣:  腫瘤生物學、生殖內分泌學、抗癌中草藥開發

 

 

2. 計畫

   

 科技部

1. 探討頭孢曲松在巴金森氏症動物模式提升認知功能與神經保護之機轉 (MOST 104-2923-H-040 -001 -MY3) 2015/1/1~2017/12/31 共同主持人

2. 第二型糖尿病相關因子對前列腺癌雄性素接受器訊息傳遞的調控(NSC 102-2320-B-040 -023) 2013/8/1~2015/7/31 主持人

3. 薯蕷皂甘素對雄性老化大鼠模型生殖功能之保護效應(102-2815-C-040-047-B) 2013/7/1~2014/2/28 指導教授

4. 老化所引發之神經退化與行為缺陷之關係:探討薯蕷皂之保護功能(100-2923-H-040-009-MY3) 2011/8/1~2014/7/31 共同主持人

 其他單位

1. 糖尿病治療藥物對於人腺癌細胞株分腺特抗原之機制(CSMU-INT-101-17) 2012/8/1~2013/7/31 主持人  中山醫學大學

2. 糖尿病對於人類正常前列腺上皮細胞以及前列腺癌細胞株增殖之影響(1000701001) 2011/8/1~2012/7/31 主持人 中山醫學大學與童綜合醫院

3. 蟾蜍靈與華蟾精對於人類雄性素依賴性前列腺癌之抗雄性素效應(G098N0018) 2010/4/1~2010/7/31 主持人 中山醫學大學

 

 

3. 學術著作

 

期刊論文

1.   Wang, Z.H., Hsu, H.W., Chou, J.C., Yu, C.H., Bau, D.T., Wang, G..J., Huang, C.Y., Wang, P.S., Wang, S.W. Cytotoxic effect of S-petasin and iso-S-petasin on the proliferation of human prostate cancer cells. Anticancer Research 2015;35:191-199. (SCI)

2.   Chu, S.C., Chen, P.N., Ho, Y.J., Yu, C.H., Hsieh, Y.S., Kuo, D.Y. Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control. Hormones and Behavior 2015;67:38-47. (SCI)

3.   Hsieh, Y.S., Chen, P.N., Yu, C.H., Kuo, D.Y. Central dopamine action modulates neuropeptide-controlled appetite via the hypothalamic PI3K/ NF-κB-dependent mechanism. Genes, Brain, and Behavior 2014;13:784-793. (SCI)

4.   Chu, S.C., Chen, P.N., Hsieh, Y.S., Yu, C.H., Lin, M.H., Lin, Y.H., Kuo, D.Y. Involvement of hypothalamic PI3K-STAT3 signaling in regulating appetite suppression mediated by amphetamine. British Journal of Pharmacology 2014;171:3223-3233. (SCI)

5.   Ho, S.C., Hsu, C.C., Yu, C.H., Huang, W.N., Tikhonova, M.A., Ho, M.C., Hung, C.S., Amstislavskaya, T.G., Ho, Y.J. Measuring ateention in a Parkinson’s disease rate model using the 5-arm maze test. Physiology & Behavior 2014;130:176-181. (SCI)

6.   Tikhonova, M.A., Yu, C.H., Kolosova, N.G., Gerlinskaya, L.A. , Yudina, A.V., Ho, Y.J., Amstislavskaya, T.G. Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactose-induced accelerated senescence: Evaluating the protective effects of diosgenin. Pharmacology, Biochemical and Behavior 2014;120:7-16. (SCI)

7.   Hsieh, Y.S., Chen, P.N., Yu, C.H., Liao, J.M., Kuo, D.Y. Inhibiting neuropeptide Y Y1 receptor modulates melanocortin receptor- and NF-κB-mediated feeding behavior in phenylpropanolamine-treated rats. Hormones and Behavior 2013;64:95-102. (SCI)

8.   Hsieh, Y.S., Chen, P.N., Yu, C.H., Liao, J.M., Kuo, D.Y. The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats. Molecular Brain 2013;6:46. (SCI)

9.   Kuo, D.Y., Chen, P.N., Yu, C.H., Kuo, M.H., Hsieh, Y.S., and Chu, S.C. Involvement of neuropeptide Y Y1 receptor in the regulation of amphetamine-mediated appetite suppression. Neuropharmacology 2012;63:842-850. (SCI)

10.Kau, M.M., Wang, J.R., Tsai, S.C., Yu, C.H., and Wang, P.S. Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of extracellular signal-regulated kinase in human adrenocortical cells. British Journal of Pharmacology 2012;165:1868-1876. (SCI)

11. Kuo, D.Y., Chen, P.N., Yang, S.F., Chu, S.C., Chen, C.H., Kuo, M.H., Yu, C.H., and Hsieh, Y.S. Role of reactive oxygen species-related enzymes in neuropeptide Y and proopiomelanocortin-mediated appetite control: a study using atypical protein kinase C knockdown. Antioxidants & Redox Signaling 2011;15:2147-2159. (SCI) NSC- 98-2320-B-040-009-MY3

12. Chen, M.C., Yu, C.H., Kan, S.F., Wang, S.W., Lin, L.C., Chi, C.W., Ho, L.T., Lee, C.H., and Wang, P.S. Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO. Journal of Cellular Biochemistry 2010;110:1495-1503.(SCI) V95D-005

13. Yu, C.H., Kan, S.F., Shu, C.H., Lu, T.J., Sun-Hwang, L., and Wang, P.S. Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo. Journal of Nutritional Biochemistry 2009;20:753-764. (SCI) NSC-92-2321-B-010-009; NSC-93-2321-B-010-009; NSC-94-2321-B-010-003

14. Yu, C.H., Kan, S.F., Pu, H.F., Jea-Chien, E., and Wang, P.S. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and –independent human prostate cancer cells. Cancer Science 2008;99:2467-2476. (SCI) CCMP97-RD-010

15. Kan , S.F., Yu, C.H., Pu, H.F., Hsu, J.M., Chen, M.J., and Wang, P.S. Antiproliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3. Journal of Cellular Biochemistry 2007;101:44-56. (SCI) NSC 95-2320-B-010-027

16. Hwang, G.S., Wang, S.W., Tseng, W.M., Yu, C.H., and Wang P.S. Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells. American Journal of Physiology-Endocrinology and Metabolism 2007;292:E1763-E1769. (SCI) NSC 94-2320-B-010-010

 

 

專書

Wang, P.S., Yeh, J.Y., Yu, C.H., and Wang S.W. Chapter 18: An Evidence-based Perspective of Bufo Gargarizans (Asiatic Toad) for Cancer Patients. Evidence-based Anticancer Materia Medica edited by Cho, W.C.S. Berlin, Germany, Springer, 2011, pp. 389-407.

 

研討會論文
 
口頭報告

1. Tsai TT, Kuo DY, Liao JM, Chen, C.H., Yu CH. 2014. Regulation of metformin on the PSA secretion and AR expression of human prostate cancer cell lines. Program and Abstract of the 2014 Meeting of Physiological Adaptation of Cancer. Taichung, Taiwan, 30-31 Aug. (Platform Session, Program #Cancer 1).

2. Yu CH. 2013. The role of diosgenin on the male reproductive function in accelerated senescence rat models. Program and Abstract of the 28th Joint Annual Conference of Biomedical Science. Taipei, Taiwan , 23-24 Mar. (Platform Session, Program # S-32).

3. Yu CH, Ho YJ, Amstislavskaya TG, Tikhonova MA, and Wang PS. 2012. Adaptation of Testicular Function in D-galactose-treated and OXYS Rat Models. Program and Abstract of the International Conference of Traditional Chinese Medicine and Adaptation to Environmental Stress. Taipei, , 21-23 Apr. (Platform Session, Program # S-13).

4. Yu CH, Chien SW, and Wang PS. 2011. The Effects of Diabetes on the Growth of Human Prostate Cancer Cells. Program and Abstract of the 2nd Cross-Strait Symposium on Adaptive Medicine and Physical Fitness. Jinan, Shandong, , 12-17 Oct. (Platform Session, Program # S-12).

5. Yu CH, Lin RC, and Wang PS. 2010. Pro-apoptotic and anti-migration effects of evodiamine and rutaecarpine on human ovarian cancer cell line SKOV3. Program and Abstract of the 1st Cross-Strait Symposium of Adaptive Medicine and Physical Fitness. Taipei, , 10-14 Sep. (Platform Session, Program # S-01).

6. Yu CH, Lin RC, and Wang PS. 2010. Anti-proliferative effects of evodiamine and rutaecarpine on human ovarian cancer cell line SKOV3. Program and Abstract of the 43rd Annual Meeting of the Society for the Study of Reproduction, Milwaukee, Wisconsin, USA, 30 July-3 Aug. (Platform Session, Program # 135).

7. Yu CH, and Wang PS. 2009. Inhibitory effects of bufalin on the growth of androgen-insensitive human prostate cancer in vitro and in vivo. Program and Abstract of the 9th World Congress of the International Society for the Adaptive Medicine, Taipei, ROC, 2 – 5 Aug. (Platform Session, Program # S-62).

8. Yu CH, Kan SF, Wang JR, Wang KL, and Wang PS. 2006. Inhibitory effects of Agaricus blazei murill on the growth of prostate cancer in vitro and in vivo. Program and Abstract of the 39th Annual Meeting of the Society for the Study of Reproduction, Omaha, USA, 29 July-1 Aug. (Platform Session, Program # 139).

9. Chow YC, Yu CH, Hsu HW, Yeh JY, and Wang PS. 2003. Antiproliferative Effects of Bufalin and Cinobufagin on Human Prostate Cancer Cell Lines. Program and Abstract of the 36th Annual Meeting of the Society for the Study of Reproduction, Cincinnati, , 19-22 July. (Platform Session, Program # 453).

海報發表

 

1. Yu, C.H., Kuo, D.Y., Liao, J.M. 2015. Alteration of stemness properties of prostate cancer cells by metformin. Program and Abstract of Clinical Applications of Stem Cells. , 26-27 Feb. (Poster Session).  

2. Meng, W.Y., Ho, S.C., Yu, C.H., Tikhonova, M.A., Amstislavskaya, T.G., Ho, Y.J. 2014. Effects of CEF on cognitive and neuronal deficits in premature aging OXYS rat. Program and Abstract of the 53rd Annual Meeting of Taiwanese Psychology. Taipei, , 8-9 Nov. (Poster Session).

3. Kuo, D.Y., Hsieh, Y.S., Chen, P.N., Yu, C.H. 2014. Involvement of Neuropeptide Y Y1 Receptor in the Regulation of Amphetamine-Mediated Appetite Suppression. Program and Abstract of 2014 The International Neuroscience Conference. Tokyo, , 28-29 Mar. (Poster Session).

4. Chen CH, Kuo DY, Liao JM, Yu 2014. Regulation of appetite on diabetic rat’s hypothalamus. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, , 15-16 Mar. (Poster Session, Program # 523).

5. Lin MY, Ho YJ, Yu 2014. Protective effect of male reproductive function in aging rat model after treatment of diosgenin. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, , 15-16 Mar. (Poster Session, Program # 718).

6. Tsai TT, Kuo DY, Liao JM, Yu 2014. Regulation of metformin on the PSA secretion and AR expression of human prostate cancer cell lines. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, , 15-16 Mar. (Poster Session, Program # 719).

7. Kuo, D.Y., Hsieh, Y.S., Chen, P.N., Yu, C.H. 2013. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Program and Abstract of 102年度「形態及生理醫學學門」成果報告暨學術交流研討會. Nantou, , 27-28 Sep. (Poster Session).

8. Kuo DY, Kuo MH, Yu 2013. The identification of neuropeptide Y receptor subtype involved in phenylpropanolamine-induced increase in oxidative stress and appetite suppression. Program and Abstract of the 28th Joint Annual Conference of Biomedical Science. Taipei, , 23-24 Mar. (Poster Session, Program # 570).

9. Kuo, D.Y., Hsieh, Y.S., Chen, P.N., Yu, C.H. 2012. Knocking down the transcript of NF-kappaBn modulates the reciprocal regulation of endogenous antioxidants and feeding behavior in phenylpropanolamine-treated rats. Program and Abstract of the 27th Joint Annual Conference of Biomedical Science. Taipei, , 17-18 Mar. (Poster Session).

10. Yu CH, Wang KL, Hsu RL, Ho YJ, and Wang PS. 2011. Modulation of diosgenin on the testosterone production and sperm motility of D-galactose-induced aging rat model. Program and Abstract of the 7th FAOPS. Taipei, , 11-14 Sep. (Poster Session, Program # P-M31).

11. Yu CH, Wang KL, Hsu RL, Ho YJ, and Wang PS. 2011. Effects of diosgenin on the reproductive function of D-galactose-induced aging model of male rats. Program and Abstract of the 44th Annual Meeting of the Society for the Study of Reproduction, Portland, Oregon, USA, 31 July-4 Aug. (Poster Session, Program # 550).

12. Wang PS, Chan CJ, Hsia SM, Wang KL, Yu CH, and Hsu RL. 2010. Effects and molecular mechanism of isoliquiritigenin on suppression of metastasis of human breast cancer cells. Program and Abstract of the 43rd Annual Meeting of the Society for the Study of Reproduction, Milwaukee, Wisconsin, USA, 30 July-3 Aug. (Poster Session, Program # 586).

13. Yu CH, Chen MC, Kan SF, and Wang PS. 2010. Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO. Program and Abstract of the Symposium of Adaptation to the Environmental Stress, Taipei, ROC, 10-11 Apr. (Poster Session, Program # P-13).

14. Kau MM, Wang JR, Tsai SC, Yu CH, Wang PS. 2010. Inhibitory effect of bufalin and cinobufagin on StAR expression via the activation of extracellular signal-regulated kinase in human adrenocortical cells. Program and Abstract of the Symposium of Adaptation to the Environmental Stress, Taipei, ROC, 10-11 Apr. (Poster Session, Program # P-12).

15. Yu CH, Chang YJ, Hsu RL, and Wang PS. 2009. Antiproliferative effects of bufalin on androgen-independent human prostate cancer in vitro and in vivo. Program and Abstract of The 36th International Congress of Physiological Sciences, Kyoto, Japan, 27 July- 1 Aug (Poster Session, Program # P1AM-17-13).

16. Wang KL, Hsia SM, Yu CH, Cho YM, Tsai YT, and Wang PS. 2009. Stimulatory effect of polybrominated diphenyl ethers on testosterone release in rat Leydig cells. Program and Abstract of The 36th International Congress of Physiological Sciences, Kyoto, , 27 July- 1 Aug (Poster Session, Program # P2AM-6-8).

17. Chan CJ, Hsia SM, Yu CH, Wang KL, and Wang PS. 2009. Effects of isoliquiritigenin on human breast cancer cells. Program and Abstract of the 9th World Congress of the International Society for the Adaptive Medicine, Taipei, ROC, 2 – 5 Aug. (Poster Session, Program # P-51).

18. Hsu RL, Hsia SM, Yu CH, Wang KL, Chan CJ, and Wang PS. 2009. The antitumor effects of isoliquiritigenin on human cervical cancer cells. Program and Abstract of the 9th World Congress of the International Society for the Adaptive Medicine, Taipei, ROC, 2 – 5 Aug. (Poster Session, Program # P-52).

19. Yu CH, and Wang PS. 2008. Antiandrogenic signaling of bufalin and cinobufagin on human prostate cancer cells. Program and Abstract of the 41st Annual Meeting of the Society for the Study of Reproduction, Hawaii, , 27-30 July (Poster Session, Program # 516).

20. Wang PS, Yu CH, and Su JC. 2008. Effects of evodiamine on the expression and secretion of vascular endothelial growth factor in human breast cancer cells. Program and Abstract of the 41st Annual Meeting of the Society for the Study of Reproduction, Hawaii, , 27-30 July (Poster Session, Program # 684).

21. Wang KL, Yu CH, Huang WJ, Jian CY, Lin CY, and Wang PS. 2008. Effects of acrolein and nicotine on the secretion of testosterone in vivo and in vitro. Program and Abstract of the 41st Annual Meeting of the Society for the Study of Reproduction, Hawaii, , 27-30 July (Poster Session, Program # 264).

22. Jian CY, Lin CY, Chang YJ, Huang WJ, Yu CH, and Wang PS. 2008. Chronic effects of amphetamine and methamphetamine on the testosterone production in rats. Program and Abstract of the 41st Annual Meeting of the Society for the Study of Reproduction, Hawaii, , 27-30 July (Poster Session, Program # 281).

 

23. Yu CH, Chen PC, and Wang PS. 2007. Involvement of reactive oxygen species in gossypol-induced inhibitory effects on human prostate cancer cells. Program and Abstract of the 40th Annual Meeting of the Society for the Study of Reproduction, Texas, , 21-25 July. (Poster Session, Program # 535).

24. Yu CH, Kan SF, Wu CI, and Wang PS. 2005. The signal transduction of bufalin- and cinobufagin-induced apoptosis in human prostate cancer cell lines. Program and Abstract of the 38th Annual Meeting of the Society for the Study of Reproduction, Quebec, , 24-27 July. (Poster Session, Program # M199).

25. Kan SF, Yu CH, Wu CI, and Wang PS. 2005. Mechanism of S-petasin-induced apoptosis in androgen-independent prostate cancer cells. Program and Abstract of the 38th Annual Meeting of the Society for the Study of Reproduction, Quebec, , 24-27 July. (Poster Session, Program # W210).

26. Yu CH, Hsu HW, Chen PC, and Wang PS. 2004. Effects of Bufalin and Cinobufagin on Human Prostate Cancer Cell lines. 12th International Congress of Endocrinology, ICE, Aug 31-Sep 04, 2004, Lisbon, . (Poster Session, Program # 349).

27. Kan SF, Yu CH, Tseng WM, Wu YC, and Wang PS. 2003. Inhibitory Effects of Evodiamine on the Growth of Human Prostate Cancer Cell Line LNCaP. Program and Abstract of the 36th Annual Meeting of the Society for the Study of Reproduction, Cincinnati, , 19-22 July. (Platform Session, Program # 477).

28. Pu HF, Yu CH, and Wang PS. 2002. Effects of Digitalis on Aldosterone Secretion in Rat Zona Glomerulosa Cells. Program and Abstract of the 4th Annual Meeting of the International Congress of Pathophysiology, Budapest, , 29, June-5, July. (Poster Session, Program # D2PS041#23P).