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分類清單
余青翰老師
姓名   余青翰 (Ching-Han Yu)
職稱   副教授
實驗室 實驗大樓四樓生理科
電話      (04) 2473-0022 ext.11655
傳真      (04) 2473-0022 ext.11655
信箱      chyu@csmu.edu.tw
 

 

 

  

1. 簡介

現任:中山醫學大學生理科    副教授 (2018.02 ~)
學歷:陽明大學生理所        博士 (2008)
經歷:中山醫學大學生理科    助理教授 (2010.02 ~2018.01)

      國立臺北護理健康大學  兼任助理教授 (2012.02~2013.06)

      靜宜大學              兼任助理教授 (2011.09~2012.01)

      陽明大學生理所        博士後研究員 (2008.09 ~ 2010.02)

      耕莘健康管理專科學校  兼任助理教授 (2009.09 ~ 2010.01)
研究興趣:  神經內分泌學、生殖內分泌學、抗癌中草藥開發

 

 

2. 計畫

   

 科技部

1. 探討頭孢曲松在巴金森氏症動物模式提升認知功能與神經保護之機轉 (MOST 104-2923-H-040 -001 -MY3) 2015/1/1~2017/12/31 共同主持人

2. 第二型糖尿病相關因子對前列腺癌雄性素接受器訊息傳遞的調控(NSC 102-2320-B-040 -023) 2013/8/1~2015/7/31 主持人

3. 薯蕷皂甘素對雄性老化大鼠模型生殖功能之保護效應(102-2815-C-040-047-B) 2013/7/1~2014/2/28 指導教授

4. 老化所引發之神經退化與行為缺陷之關係:探討薯蕷皂之保護功能(100-2923-H-040-009-MY3) 2011/8/1~2014/7/31 共同主持人

 其他單位

1. 產學合作計畫 (華廣生技股份有限公司)2018/3/6~2018/9/5  主持人

2. 產學合作計畫 (禎和先進技術開發有限公司)2018/1/1~2018/6/30  主持人

3. 產學合作計畫 (華廣生技股份有限公司)2017/9/15~2018/2/14  主持人

4. 中興大學-中山醫學大學跨校計畫 2017/1/1~2017/12/31  主持人

5. 中山醫學大學校內計畫 2016/10/1~2017/7/31  主持人

6. 中山醫學大學校內計畫 2012/8/1~2013/7/31  主持人

7. 童綜合醫院-中山醫學大學跨院計畫 2011/8/1~2012/7/31  主持人

8. 中山醫學大學校內計畫 2010/4/1~2010/7/31  主持人

 

3. 學術著作

期刊論文

  1. Yu, C.H., Hsieh, Y.S., Chen, P.N., Chen, J.R., and Kuo, D.Y. Knockdown of the transcript of extracellular signal-regulated kinase in the brain modulated hypothalamic neuropeptide-mediated appetite control in amphetamine-treated rats. British Journal of Pharmacology 2018;175:726-739.
  2. Kau, M.M., Yu, C.H., Tsai, S.C., Wang, J.R., and Wang, P.S. Stimulatory effect of food restriction on the steroidogenesis of aldosterone in ovariectomized rats. Chinese Journal of Physiology 2017;60:97-105.
  3. Yu, C.H., Chu, S.C., Chen, P.N., Hsieh, Y.S., and Kuo, D.Y. Participation of ghrelin signalling in the reciprocal regulation of hypothalamic NPY/POMC-mediated appetite control in amphetamine-treated rats. Appetite 2017;113:30-40.
  4. Yu, C.H., Chu, S.C., Chen, P.N., Hsieh, Y.S., and Kuo, D.Y. Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine: Role of oxidative stress in controlling ghrelin/NPY/CART-mediated appetite. Genes, Brain, and Behavior 2017;16:439-448.
  5. Chu, S.C., Yu, C.H., Chen, P.N., Hsieh, Y.S., and Kuo, D.Y. Role of oxidative stress in disrupting the function of negative glucocorticoid response element in daily amphetamine-treated rats. Psychoneuroendocrinology 2016;71:1-11.
  6. Chien, S.W., Kuo, D.Y., Liao, J.M., Wang, P.S., and Yu, C.H.* Growth modulation of diabetic factors and antidiabetic drugs on prostate cancer cell lines. Chinese Journal of Physiology 2016;59:109-118.
  7. Hsieh, Y.S., Chen, P.N., Yu, C.H., Chen, C.H., Tsai, T.T., and Kuo, D.Y. Involvement of oxidative stress in the regulation of NPY/CART- mediated appetite control in amphetamine-treated rats. Neurotoxicology 2015;48:131-141.
  8. Wang, Z.H., Hsu, H.W., Chou, J.C., Yu, C.H., Bau, D.T., Wang, G.J., Huang, C.Y., Wang, P.S., and Wang, S.W. Cytotoxic effect of S-petasin and iso-S-petasin on the proliferation of human prostate cancer cells. Anticancer Research 2015;35:191-199.
  9. Chu, S.C., Chen, P.N., Ho, Y.J., Yu, C.H., Hsieh, Y.S., and Kuo, D.Y. Both neuropeptide Y knockdown and Y1 receptor inhibition modulate CART-mediated appetite control. Hormones and Behavior 2015;67:38-47.
  10. Hsieh, Y.S., Chen, P.N., Yu, C.H., and Kuo, D.Y. Central dopamine action modulates neuropeptide-controlled appetite via the hypothalamic PI3K/ NF-κB-dependent mechanism. Genes, Brain, and Behavior 2014;13:784-793.
  11. Chu, S.C., Chen, P.N., Hsieh, Y.S., Yu, C.H., Lin, M.H., Lin, Y.H., and Kuo, D.Y. Involvement of hypothalamic PI3K-STAT3 signalling in regulating appetite suppression mediated by amphetamine. British Journal of Pharmacology 2014;171:3223-3233.
  12. Ho, S.C., Hsu, C.C., Yu, C.H., Huang, W.N., Tikhonova, M.A., Ho, M.C., Hung, C.S., Amstislavskaya, T.G., and Ho, Y.J. Measuring attention in a Parkinson’s disease rat model using the 5-arm maze test. Physiology & Behavior 2014;130:176-181.
  13. Tikhonova, M.A., Yu, C.H., Kolosova, N.G., Gerlinskaya, L.A., Maslennikova, S.O., Yudina, A.V., Amstislavskaya, T.G. and Ho, Y.J. Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactose-induced accelerated senescence: Evaluating the protective effects of diosgenin. Pharmacology, Biochemistry and Behavior 2014;120:7-16.
  14. Hsieh, Y.S., Chen, P.N., Yu, C.H., Liao, J.M., and Kuo, D.Y. Inhibiting neuropeptide Y Y1 receptor modulates melanocortin receptor- and NF-κB-mediated feeding behavior in phenylpropanolamine-treated rats. Hormones and Behavior 2013;64:95-102.
  15. Hsieh, Y.S., Chen, P.N., Yu, C.H., Liao, J.M., and Kuo, D.Y. The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats. Molecular Brain 2013;6:46.
  16. Kuo, D.Y., Chen, P.N., Yu, C.H., Kuo, M.H., Hsieh, Y.S., and Chu, S.C. Involvement of neuropeptide Y Y1 receptor in the regulation of amphetamine-mediated appetite suppression. Neuropharmacology 2012;63:842-850.
  17. Kau, M.M., Wang, J.R., Tsai, S.C., Yu, C.H., and Wang, P.S. Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells. British Journal of Pharmacology 2012;165:1868-1876.
  18. Kuo, D.Y., Chen, P.N., Yang, S.F., Chu, S.C., Chen, C.H., Kuo, M.H., Yu, C.H., and Hsieh, Y.S. Role of reactive oxygen species-related enzymes in neuropeptide Y and proopiomelanocortin-mediated appetite control: a study using atypical protein kinase C knockdown. Antioxidants & Redox Signaling 2011;15:2147-2159.
  19. Chen, M.C., Yu, C.H., Kan, S.F., Wang, S.W., Lin, L.C., Chi, C.W., Ho, L.T., Lee, C.H., and Wang, P.S. Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO. Journal of Cellular Biochemistry 2010;110:1495-1503.
  20. Yu, C.H., Kan, S.F., Shu, C.H., Lu, T.J., Sun-Hwang, L., and Wang, P.S. Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo. Journal of Nutritional Biochemistry 2009;20:753-764.
  21. Yu, C.H., Kan, S.F., Pu, H.F., Jea-Chien, E., and Wang, P.S. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and –independent human prostate cancer cells. Cancer Science 2008;99:2467-2476.
  22. Kan, S.F., Yu, C.H., Pu, H.F., Hsu, J.M., Chen, M.J., and Wang, P.S. Antiproliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3. Journal of Cellular Biochemistry 2007;101:44-56.
  23. Hwang, G.S., Wang, S.W., Tseng, W.M., Yu, C.H., and Wang P.S. Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells. American Journal of Physiology-Endocrinology and Metabolism 2007;292:E1763-E1769.  

 

專書

Wang, P.S., Yeh, J.Y., Yu, C.H., and Wang S.W. Chapter 18: An Evidence-based Perspective of Bufo Gargarizans (Asiatic Toad) for Cancer Patients. Evidence-based Anticancer Materia Medica edited by Cho, W.C.S. Berlin, Germany, Springer, 2011, pp. 389-407.

 
 
研討會論文
 
 
口頭報告

1. Tsai TT, Kuo DY, Liao JM, Chen, C.H., Yu CH. 2014. Regulation of metformin on the PSA secretion and AR expression of human prostate cancer cell lines. Program and Abstract of the 2014 Meeting of Physiological Adaptation of Cancer. Taichung, Taiwan, 30-31 Aug. (Platform Session, Program #Cancer 1).

2. Yu CH. 2013. The role of diosgenin on the male reproductive function in accelerated senescence rat models. Program and Abstract of the 28th Joint Annual Conference of Biomedical Science. Taipei, Taiwan , 23-24 Mar. (Platform Session, Program # S-32).

3. Yu CH, Ho YJ, Amstislavskaya TG, Tikhonova MA, and Wang PS. 2012. Adaptation of Testicular Function in D-galactose-treated and OXYS Rat Models. Program and Abstract of the International Conference of Traditional Chinese Medicine and Adaptation to Environmental Stress. Taipei, , 21-23 Apr. (Platform Session, Program # S-13).

4. Yu CH, Chien SW, and Wang PS. 2011. The Effects of Diabetes on the Growth of Human Prostate Cancer Cells. Program and Abstract of the 2nd Cross-Strait Symposium on Adaptive Medicine and Physical Fitness. Jinan, Shandong, , 12-17 Oct. (Platform Session, Program # S-12).

5. Yu CH, Lin RC, and Wang PS. 2010. Pro-apoptotic and anti-migration effects of evodiamine and rutaecarpine on human ovarian cancer cell line SKOV3. Program and Abstract of the 1st Cross-Strait Symposium of Adaptive Medicine and Physical Fitness. Taipei, , 10-14 Sep. (Platform Session, Program # S-01).

6. Yu CH, Lin RC, and Wang PS. 2010. Anti-proliferative effects of evodiamine and rutaecarpine on human ovarian cancer cell line SKOV3. Program and Abstract of the 43rd Annual Meeting of the Society for the Study of Reproduction, Milwaukee, Wisconsin, USA, 30 July-3 Aug. (Platform Session, Program # 135).

7. Yu CH, and Wang PS. 2009. Inhibitory effects of bufalin on the growth of androgen-insensitive human prostate cancer in vitro and in vivo. Program and Abstract of the 9th World Congress of the International Society for the Adaptive Medicine, Taipei, ROC, 2 – 5 Aug. (Platform Session, Program # S-62).

8. Yu CH, Kan SF, Wang JR, Wang KL, and Wang PS. 2006. Inhibitory effects of Agaricus blazei murill on the growth of prostate cancer in vitro and in vivo. Program and Abstract of the 39th Annual Meeting of the Society for the Study of Reproduction, Omaha, USA, 29 July-1 Aug. (Platform Session, Program # 139).

9. Chow YC, Yu CH, Hsu HW, Yeh JY, and Wang PS. 2003. Antiproliferative Effects of Bufalin and Cinobufagin on Human Prostate Cancer Cell Lines. Program and Abstract of the 36th Annual Meeting of the Society for the Study of Reproduction, Cincinnati, , 19-22 July. (Platform Session, Program # 453).

 

海報發表(近五年)

1. Kuo DY, Yu CH, Hsieh YS, Chen PN, Liao JM. 2017. Role of oxidative stress in disrupting the function of negative glucocorticoid response element in daily amphetamine-treated rats. Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # PY019).

2. Kuo DY, Yu CH, Hsieh YS, Chen PN, Liao JM. 2017. Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine. Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # PY020).

3. Kuo DY, Yu CH, Hsieh YS, Chen PN, Liao JM. 2017. Involvement of neuropeptide Y Y1 receptor in the regulation of amphetamine-mediated appetite suppression. Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # PY021).

4. 林真襄、李旻軒、沈怡廷、巖正傑、余青翰2017硝酸鹽及亞硝酸鹽對小鼠記憶學習能力的影響。Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # TX051).

5. 李旻軒, 巖正傑, 余青翰, 葉心。2017Anti-hyperlipidemia and Neroprotective Effects of Resveratrol on High-fat Fed Hamster. Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # TX075).

6. Wu MF, Kuo DY, Liao JM, Yu CH. 2017. Inhibitory Effects of Diosgenin on the Testosterone Production of Leydig Cell and on the Sperm Quality of Male Rat. Program and Abstract of the 32nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 25-26 Mar. (Poster Session, Program # PY172).

7. Yu CH, Lin YC, Liao JM, Kuo DY, Yen CC. 2016. Protective effect of resveratrol in hamsters on a high-fat diet. Program and Abstract of the International Symposium of Reproduction and Metabolism. Taipei, Taiwan, 1-2 Oct. (Poster Session, Program # P01).

8. Kuo DY, Yu CH, Hsieh YS, Chen PN, Liao JM. 2016. Involvement of hypothalamic NF-kappaB in the regulateon of catecholamine-mediated appetite suppression. Program and Abstract of the 31st Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 26-27 Mar. (Poster Session, Program # 757).

9. Kuo DY, Yu CH, Hsieh YS, Chen PN, Liao JM. 2016. Role of oxidative stress in disrupting the function of negative DNA-glucocorticoid response element in amphetamine-treated rats. Program and Abstract of the 31st Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 26-27 Mar. (Poster Session, Program # 758).

10. Wang HL, Wu MF, Kuo DY, Liao JM, Yu CH. 2015. Metformin reduces stemness properties of prostate cancer cells. Program and Abstract of the 30th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 21-22 Mar. (Poster Session, Program # 645).

11. Chen CH, Tsai TT, Yu CH, Liao JM, Kuo DY. 2015. The role of plasma ghrelin in the regulation of amphetamine-induced appetite suppression in rats. Program and Abstract of the 30th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 21-22 Mar. (Poster Session, Program # 637).

12. Meng, W.Y., Ho, S.C., Yu, C.H., Tikhonova, M.A., Amstislavskaya, T.G., Ho, Y.J. 2015. Cognitive and neuronal deficits in premature aging OXYS rats: CEF treatment. Program and Abstract of the 30th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 21-22 Mar. (Poster Session, Program # 435).

13. Yu, C.H., Kuo, D.Y., Liao, J.M. 2015. Alteration of stemness properties of prostate cancer cells by metformin. Program and Abstract of Clinical Applications of Stem Cells. Singapore, 26-27 Feb. (Poster Session, Program # 1010).

14. Meng, W.Y., Ho, S.C., Yu, C.H., Tikhonova, M.A., Amstislavskaya, T.G., Ho, Y.J. 2014. Effects of CEF on cognitive and neuronal deficits in premature aging OXYS rat. Program and Abstract of the 53rd Annual Meeting of Taiwanese Psychology. Taipei, Taiwan, 8-9 Nov. (Poster Session).

15. Kuo, D.Y., Hsieh, Y.S., Chen, P.N., Yu, C.H. 2014. Involvement of Neuropeptide Y Y1 Receptor in the Regulation of Amphetamine-Mediated Appetite Suppression. Program and Abstract of 2014 The International Neuroscience Conference. Tokyo, Japan, 28-29 Mar. (Poster Session).

16. Chen CH, Kuo DY, Liao JM, Yu CH. 2014. Regulation of appetite on diabetic rat’s hypothalamus. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 15-16 Mar. (Poster Session, Program # 523).

17. Lin MY, Ho YJ, Yu CH. 2014. Protective effect of male reproductive function in aging rat model after treatment of diosgenin. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 15-16 Mar. (Poster Session, Program # 718).

18. Tsai TT, Kuo DY, Liao JM, Yu CH. 2014. Regulation of metformin on the PSA secretion and AR expression of human prostate cancer cell lines. Program and Abstract of the 29th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 15-16 Mar. (Poster Session, Program # 719).

19. Kuo, D.Y., Hsieh, Y.S., Chen, P.N., Yu, C.H. 2013. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. Program and Abstract of 102年度「形態及生理醫學學門」成果報告暨學術交流研討會. Nantou, Taiwan, 27-28 Sep. (Poster Session).

20. Kuo DY, Kuo MH, Yu CH. 2013. The identification of neuropeptide Y receptor subtype involved in phenylpropanolamine-induced increase in oxidative stress and appetite suppression. Program and Abstract of the 28th Joint Annual Conference of Biomedical Science. Taipei, Taiwan, 23-24 Mar. (Poster Session, Program # 570).