學歷

中山醫學大學生物暨生物科技研究所博士

經歷

1. 中山醫學大學醫學系寄生蟲學科 技士 2002-迄今

2. 中山醫學大學醫學系寄生蟲學科 技佐 1999-2002

3. 中山醫學大學醫學系寄生蟲學科 兼任講師 2007-迄今

專長

1.    寄生蟲學 2. 分子生物學

論文著作

1.      Lai, S. C., Chen, K. M., Yang, J. P., Liu, J. P., Hsu, C. C., Lee, Y. H., Jen, S. Y., Huang, J. W., and Lee, H. H. 2003. Upregulation of MMP-9 in mouse cerebellum with Purkinje cell loss caused by Angiostrongylus cantonensis. The Chung-Shan Medical Journal 14: 485-493

2.      Lan, K. P., Wang, C. J., Lai, S. C. Chen, K. M., Lee, S. S., Hsu, J. D., and Lee, H. H. 2004. The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitology Research 93: 311-317. (SCI)

3.      Chen, K. M., Lee, H. H., Lu, K. H., Tseng, Y. K., Hsu, L. S., Chou, H. L., and Lai, S. C. 2004. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. International Journal for Parasitology 34: 1147-1156. (SCI)

4.      Lai, S. C., Twu, J. J., Jiang, S. T., Hsu, J. D., Chen, K. M., Chiaing, H. C., Wang, C. J., and Lee, H. H. 2004. Induction of matrix-metalloproteinase-9 in the pathogenesis of eosinophilic meningitis caused by Angiostrongylus cantonensis. Annal Tropical and Medicine and Parasitology 98: 715-724. (SCI)

5.      Lee, H. H., Chou, H. L., Chen, K. M., Lai, S. C. 2004. Association of matrix-metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitology Research 94: 321-328. (SCI)

6.      Hou, R. F., Tu, W. C., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2004. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. International Journal for Parasitology 34: 1355-1364. (SCI)

7.      Lan, K. P., Wang, C. J., Hsu, J. D., Chen, K. M., Lai, S. C. and Lee, H. H. 2004. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mice brain is associated with the induction of JAK/STAT1, IAP/NF-κB and MEKK1/JNK signals. Journal of Helminthology 78: 311-317. (SCI)

8.      Tseng, Y. K., Tu, W. C., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2004. Ultrastructural localization of matrix metalloproteinase-9 in CSF eosinophils of mice with eosinophilic meningitis. Annal Tropical and Medicine and Parasitology. 98: 831-841. (SCI)

9.      Chen, K. M., Lee, H. H., Tsai, B. C., Kung, C. C., and Lai, S. C. 2004. Association of matrix metalloproteinases with blood-brain barrier damage of angiostrongyliasis. The Chung-Shan Medical Journal 15: 195-204.

10.  Hsu, L. S., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2005. Matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. Annal Tropical and Medicine and Parasitology 99: 61-70. (SCI)

11.  Lai, S. C., Jiang, S. T., Chen, K. M., Hsu, J. D., Shyu, L. Y., and Lee, H. H. 2005. Efficacy of albendazole–GM6001 co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. Acta Tropica 93: 267-173. (NSC-90-2320-B-040-015) (SCI)

12.  Lai, S. C., Chen, K. M., Chen, H. C. Lee, H. H. 2005. Induction of matrix metalloproteinase- 9 in mice during Toxocara canis larvae migration. Parasitology Research 95: 193-200. (SCI)

13.  Chen, K. M., Lee, H. H., Chou, H. L., Liu, J. Y., Tsai, B. C., Lai, S. C. 2005. Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. International Journal of Experimental Pathology 86: 81-89. (SCI)

14.  Lai, S. C., Jiang, S. T., Chen, K. M., Lee, H. H. 2005. Matrix metalloproteinases activity demonstrated in the infective stage of the nematodes, Angiostrongylus cantonensis. Parasitology research. 97:466-471. (SCI)

15.  Chen, K. M., Li, S. C., Lai, C. Y., Jiang, S. T. Lee, H. H. 2006. Efficacy of N-acetylcysteine or GM6001 therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. The Chung-Shan Medical Journal 16: 285-294.

16. Chen, K. M., Liu, J. Y., Lai, S. C., Hsu, L. S. and Lee, H. H. 2006. Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis International Journal of Experimental Pathology 87, 113-119. (SCI)

17. Chen, K. M., Wang, C. P. and Lai, S. C.* 2006. Albendazole and Long-Dan-Cao co-therapy against Angiostrongylus cantonensis-induced matrix metalloproteinase-9 and eosinophilic meningitis. The Chung-Shan Medical Journal 17, 63-70.

18. Chen, K. M. and Lai, S. C.* 2007. Biochemical and pathological evaluation of albendazole-thalidomide co-therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. Journal of Antimicrobial Chemotherapy 59, 264-276 (SCI)

19. Shih, P. C. Lee, H. H. Lai, S. C. Chen, K. M. Jiang, S. T. Chen, Y. F. Shiow, S. J. 2007. Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. Journal of Helminthology 81, 1-5. (SCI)

20. Tu, W. C., Chen, H. C., Chen, K. M., Tang, L. C. and Lai, S. C.* 2007. Intestinal myiasis caused by larvae of Telmatoscopus albipunctatus in a Taiwanese man. Journal of Clinical Gastroenterology 41, 400-402. (SCI)

21. Ke-Min Chen, Hsiu-Hsiung Lee, Shih-Chan Lai, Li-Sung Hsu, Chau-Jong Wang, Jer-Yuh Liu *. 2008. Apoptosis in meningoencephalitis of Angiostrongylus cantonensis-infected mice. Experimental Parasitology 119, 385–390. (SCI)

Conference paper

1.          Lai, S. C., Jiang, S. T., Shyu, L. Y., Chen, K. M., and Lee, H. H. 2002. The efficacy of combining therapy with albendazole and GM6001 in parasitic meningitis caused by Angiostrongylus cantonensis-infected mice. The Seventeenth Joint Annual Conference of Parasitology, Tainan . P. 20.

2.          Lai, S. C., Shyu, L. Y., Chen, K. M., Lee, H. H. 2003. MMP-9 and its inhibitor in mice with parasitic meningitis caused by Angiostrongylus cantonensis.The First Meeting of the China and Taiwan Parasitology, Taipei. P.131.

3.          Yang, J. P., Lee, H. H., Chen, K. M., Liu, J. P., Hsu, C. C., Lee, Y. H., Jen, S. Y., Huang, J. W., and Lai. S. C. 2003. The role of MMP-9 in mice cerebellum with Purkinje cell degeneration caused by Angiostrongylus cantonensis. The Eighteenth Joint Annual Conference of Parasitology, Taipei . P. 34.

4.          Lan, K. P., Wang, C. J., Hsu, J. D., Chen, K. M., Lai, S. C., Lee, H. H. 2003. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mice brain is associated with the induction of JAK/STAT1, IAP/NFκB and MEKK1/JNK signals. The Eighteenth Joint Annual Conference of Parasitology, Taipei . P. 33.

5.          Liu, J. P., Chen, K. M., Lee, H. H., Huang, J. W., Lai, S. C. 2004. Efficacy of albendazole-dexamethasone co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Eighth Asian-Pacific Congress for Parasitic Zoonoses (8th APCPZ), . P. 41.

6.          Tsai, B. C., Chen, K. M., Lee, H. H., Wu, C. H., Lai, S. C. 2004. Induction of plasminogen activators in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. The Eighth Asian-Pacific Congress for Parasitic Zoonoses (8th APCPZ), . P. 42.

7.          Liu, J. P., Lee, H. H., Chen, K. M., Kuan, I. T., Lai, S. C. 2004. Efficacy of albendazole-dexamethasone co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Nineteenth Joint Annual Conference of Parasitology, Taichung . P. 25.

8.          Tsai, B. C., Lee, H. H., Chen, K. M., Wu, C. H., Lai, S. C. 2004. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis  The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 26.

9.          Chang,Y. H., Lai, S. C., Chen, K. M., Hsu, Y. L., Lee, H. H. 2004. Efficacy of albendazole and Long-dan-xie-gan-tan co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Nineteenth Joint Annual Conference of Parasitology, Taichung . P. 40.

10.      Jen, S. Y., Lee, H. H., Chen, K. M., Lee, Y. H., Lai, S. C. 2004. Matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. The Nineteenth Joint Annual Conference of Parasitology, Taichung . P. 41.

11.      Huang, J. W., Lee, H. H., Chen, K. M., Hsu, C. C., Lai, S. C. 2004 Ultrastructural localization of matrix metalloproteinase-9 in CSF eosinophils of mice with eosinophilic meningitis. The Nineteenth Joint Annual Conference of Parasitology, Taichung . P. 42.

12.      Chen, K. C. Lee, H. H., Chen, K. M., Chang, S. F., Lee, C. Y., Lai, S. C. 2004. Association of matrix metalloproteinases with blood-brain barrier damage of angiostrongyliasis. The Nineteenth Joint Annual Conference of Parasitology, Taichung . P. 43.

13.      Chen, K. M., Kuan, I. T., Lai, S. C. 2005. The roles of matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei . P. 333.

14.      Chen, K. M., Wu, C. H., Lai, S. C. 2005. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei . P. 362.