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分類清單
魏正宗副教授
 

魏 正 宗 醫師,醫學博士                 

 

James Cheng-Chung Wei, MD.,PhD.      

 

台中市 402南區建國北路一段110

 

(TEL) 04-24739595#34718, 34309 (FAX)04-24734323         

 

現任:

 

中山醫學大學附設醫院過敏免疫風濕科主任; 中藥臨床試驗中心主任

 

中山醫學大學醫學研究所副教授

 

中國醫藥大學中西醫結合研究所兼任副教授

 

 

學歷:

 

中山醫學大學醫學研究所博士

 

中國醫藥大學中西醫結合研究所碩士班

 

國立陽明大學醫學系

 

英國皇家國立風濕病醫院(RNHRD)研究進修

 

法國巴黎第五大學Colchin醫院進修

 

美國加州大學UCLA免疫風濕實驗室研究員

 

 

經歷: 

 

台中榮總家庭醫學科醫師   

 

高雄榮總過敏免疫風濕科總醫師

 

過敏免疫科、風濕科、內科、家醫科、中西結合專科醫師

 

嘉義榮民醫院家庭醫學科主任

 

中華民國僵直性脊椎炎關懷協會第二屆理事長

 

中山醫學大學附設醫院人體試驗委員會主任委員

 

行政院衛生署人體試驗/研究倫理委員會訪查委員

 

 

訓練:

 

中正大學企管班,行銷管理學分班。

 

中國醫藥學院中醫學分班。榮總傳統醫學中心針灸班。

 

中醫藥科學化暨全球智材及管理策略人才培訓班

 

 

醫學會:

 

國際臨床骨質密度診斷協會(ISCD)認證會員(Certified Clinical Densitometry Clinician)

 

美國臨床研究專業協會(ACRP)認證會員(Certified Physician Investigator, ICH-I-0306-006)

 

美國風濕病學院(ACR) 院士

 

美國家庭醫學學院(AAFP) 會員

 

美國自然醫學會 (ANMA) 會員暨專科醫師(Naturopathy Doctor)

 

國際僵直性脊椎炎研究組織(ASIF, ASAS)會員

 

中華醫學生物免疫學會常務理事

 

中華民國免疫學會監事,中華民國風濕病醫學會監事

 

中華民國家庭醫學醫學會,並任繼續教育委員會及資訊委員會委員。

 

中華民國風濕病醫學會,並任病人教育委員會主席、公關委員會及資訊委員會委員。

 

內科醫學會、過敏免疫醫學會、超音波醫學會、預防醫學會、老年醫學會、健診學會、中西整合醫學會會員。

 

 

榮譽:

 

2010.10 FDA GCP SITE INSPECTION PASSED

 

2010中山醫學大學優秀論文獎

 

2009中華民國風濕病醫學會優秀論文獎

 

2007中山醫學大學學生票選優良教師

 

2006中山醫學大學附設醫院教學優良獎

 

2001嘉義榮民醫院優良醫師

 

 

著作:

 

曾發表免疫風濕、僵直性脊椎炎及家庭醫學專業論文60餘篇。

 

 

專書:”Intern Guide”、“AS相隨的日子”、“僵直性脊椎炎” 三本專書。

 

 

專長:僵直性脊椎炎 風濕病 過敏 免疫 痛風 臨床試驗 整合醫學

 

 

期刊編審:

 

Lead guest editor: Biomedical Research International

 

Editorial board: International Journal of Rheumatic Diseases;  Advances in Medicine

 

Reviewer: Annals of Rheumatic Diseases, Arthritis Care & Research, Journal of Rheumatology, Clinical Rheumatology, Formosan Journal of Rheumatology

 

 


 

簡歷:

 

     魏正宗醫師,現任中山醫學大學附設醫院過敏免疫風濕科主任,中藥臨床試驗中心主任。過去曾任台中榮總、高雄榮總醫師及嘉義榮民醫院家庭醫學科主任,本身也是僵直性脊椎炎的患者。民國八十五年,魏正宗和許多病友共同組成了「中華民國僵直性脊椎炎關懷協會」,並擔任第二屆理事長。同時,他也架設了許多相關的網站,多年以來一直致力於僵直性脊椎炎的衛教與研究。

 

為了研究僵直性脊椎炎,魏正宗在20002001年出國進修,到英國皇家國立風濕病醫院(RNHRD)隨知名的僵直性脊椎炎臨床大師Andrei Calin學習僵直性脊椎炎的流行病學研究及臨床評估方法、將BASDAI, BASFI, BAS-G等僵直性脊椎炎臨床評估量表帶回國內。到法國隨Maxime Dougados學習僵直性脊椎炎的藥物臨床試驗、跟Maxime Breban認識HLA-B27基因轉殖大鼠的實驗。2004年獲得藤澤基金會獎學金,到東京大學醫科學研究所免疫風濕科Chikao Morimoto Hirotoshi Tanaka教授實驗室參訪研究。20012004年間也曾多次至美國UCLA David Yu教授的實驗室學習脊椎炎的microarray實驗及致病機轉的研究。

 

魏正宗曾經完成台灣首次僵直性脊椎炎的HLA-B27亞型的分析,並在第一屆世界脊椎炎大會發表(J. of Rheumatology. Vol 25, suppl 54: 27, 1998)。2001年與榮總合作完成以免疫磁珠法測量HLA-B27抗原之報告(J. Immunol Methods. 2001;255:15-22)2003年發表以thalidomide治療僵直性脊椎炎的臨床試驗(Journal of Rheumatology 2003;30(12):2627-31.)。2004年完成HLA-B27陰性之僵直性脊椎炎病人的MHC class I研究,發現HLA-B60B61基因亦與國人之僵直性脊椎炎有相關(Rheumatology 2004;43:839-42)。2006年發現僵直性脊椎炎病人的血中同半胱氨酸濃度過高,需補充維他命B群及葉酸。(Clin Rheumatol. 2007 May;26(5):739-42.2007年完成台灣版僵直性脊椎炎病人評估問卷之信效度評估(Clin Rheumatol 2007; 26:16851691)。20076月以台灣僵直性脊椎炎資料庫~流行病學、臨床評估量表之信效度、血中發炎指標及HLA基因型分析取得博士學位。2009年發表兩篇重要論文於頂尖醫學雜誌:台灣僵直性脊椎炎病人MMP3/TIMP基因多型性(Annals of the Rheumatic Diseases. 2009;68:17816)及RGS1基因用於鑑別診斷脊椎關節炎與機械性下背痛(Arthritis & rheumatism Vol. 60, No. 11, November 2009, 326979)2010年提出PD-1, OPG, RANKL, CTLA4基因與台灣僵直性脊椎炎相關;2011年首次提出ORAI1, IL-12B基因與台灣僵直性脊椎炎相關. 也曾經多次在國內外醫學會發表;薦腸關節局部類固醇注射;以磁振造影診斷早期薦腸關節炎;僵直性脊椎炎病人之破骨細胞培養;僵直性脊椎炎之中藥方劑療效評估等研究;臨床試驗之研究設計等。

 

魏正宗現為美國風濕病學院(ACR) 院士,美國家庭醫學學院(AAFP) 會員,美國自然醫學會 (ANMA) 會員暨專科醫師,國際僵直性脊椎炎研究組織(ASIF, ASAS)會員。近年來致力於臨床研究,曾任中山醫學大學附設醫院人體試驗委員會主任委員,並通過美國臨床研究專業協會(ACRP)認證會員(Certified Physician Investigator)

 

目前,魏正宗致力於僵直性脊椎炎、乾癬、痛風、過敏的轉譯醫學與臨床研究,過去五年共執行約三十件跨國或學術臨床試驗,並推廣中西整合與自然醫學,擔任中山醫學大學附設醫院過敏免疫風濕科主任、中藥臨床試驗中心主任及中草藥暨保健食品研究群執行長,執行過敏及免疫疾病之西藥、中草藥及保健食品臨床試驗。

 

 


 

 

代表性著作

 

1.       CHIEN-YING LEE, MIN-CHIEN YU, WUU-TSUN PERNG, CHUN-CHE LIN, MING-YUNG LEE, JAMES CHENG-CHUNG WEI* AND HUNG-CHE SHIH No Cholesterol-Lowing Additional Effect in Hyperlipidemia Patients Treated with Red Yeast Rice Combined with Lactobacillus Casei. Chinese Journal of Integrative Medicine 2013. (SCI. IF 0.799, ranking 16/22) *Equal Correspondence (accepted)

 

2.       MJ Wu, James Cheng-Chung Wei. Degenerative disc segmentation and diagnosis technology using important features from MRI of spine in images. Biomedical engineering 2013, accepted. (SCI)

 

3.       Eva L Kneepkens, James Cheng-Chung Wei, Michael T Nurmohamed, Kai-Jieh Yeo, C Y Chen, Irene E van der Horst-Bruinsma, Desiree van der Kleij, Theo Rispens, Gertjan Wolbink, Charlotte L M Krieckaert. Immunogenicity, adalimumab levels and clinical response in ankylosing spondylitis patients during 24 weeks of follow-up. Ann Rheum Dis 2013 Dec;0:16. doi:10.1136/annrheumdis-2013-204185

 

4.       Deng-Ho Yang, Chuan-Chou Tu, Shou-Cheng Wang, Cheng-Chung Wei, Ya-Wen Cheng. Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease. Rheumatology international 2013 Dec 10.1007/s00296-013-2926-6 (SCI, IF=2.2, ranking 16/29)

 

5.       Huang CH, Wei JC, Chen CC, Chuang CS, Chou CH, Lin YJ,Wang MF, Wong RH. Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis. Rheumatol Int. 2013 Nov 9. [Epub ahead of print] *Co-first author.

 

6.       Chyong-Mei Chen, James Cheng-Chung Wei, Chao-Min Hsue and Ming-Yung Leea. Regression analysis of multivariate current status data with dependent censoring: application to ankylosing spondylitis data. Statistics in medicine. 2013 Sep. Published online in Wiley Online Library, DOI: 10.1002/sim.5985.

 

7.       Josef S Smolen, Jürgen Braun, Maxime Dougados, Paul Emery, Oliver FitzGerald, Philip Helliwell, Arthur Kavanaugh, Tore K Kvien, Robert Landewé, Thomas Luger, Philip Mease, Ignazio Olivieri, John Reveille, Christopher Ritchlin, Martin Rudwaleit, Monika Schoels, Joachim Sieper, Martinus de Wit, Xenofon Baraliakos, Neil Betteridge, Ruben Burgos-Vargas, Eduardo Collantes-Estevez, Atul Deodhar, Dirk Elewaut, Laure Gossec, Merryn Jongkees, Mara Maccarone, Kurt Redlich, Filip van den Bosch, James Cheng-Chung Wei, Kevin Winthrop, Désirée van der Heijde.Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Ann Rheum Dis. 2013 Jun 8. [Epub ahead of print]

 

8.       Wei JC, Hsu YW, Hung KS, Wong RH, Huang CH, Liu YT, Guo YC, Ikegawa S, Chang WC. Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population. PLoS One. 2013 Jan;8(1):e52801. doi: 10.1371/journal.pone.0052801. (SCI, Impact factor: 3.730Ranking: 7/5612%)

 

9.       Jhi-Kai Chang, Chen-Tung Yu, Ming-Yung Lee , KJ Yeo, I-Chang Chang, Hsikai Tsou, James Cheng-Chung Wei. Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis. Clin Rheumatol. 2013 Mar; 32:341347 (SCI, Impact factor:2.037; Ranking:18/29; 64%) *Correspondence

 

10.    Pui Ying Leong, Chia-Yin Chen, Chun-Huang Huang, Yi-Ling Chen, Kai-Jieh Yeo, Jaw-Ming Cherng, Soo-Ray Wang, Gregory J Tsay, Pei-Jer Chen, James Cheng-Chung Wei*. Estimated Risk of Hepatocellular Carcinoma in Chronic Hepatitis B patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Tumor Necrosis Factor Blockers. Formosan Journal of Rheumatology 2012:26;116-24 * Correspondence

 

11.    Chien-Ying Lee, Ming-Shiou Jan, Min-Chien Yu, Chun-Che Lin, James Cheng-Chung Wei*, and Hung-Che Shih* Relationships between Adiponectin and Leptin and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice. Forschende Komplementärmedizin (Research in Complimentary Medicine). 2013 Apr;20(172) DOI:10.1159/000250035 (Impact Factor: 1.279, ranking 11/21; 52%). *Co-Correspondence

 

12.    Chien-Ying Lee, Min-Chien Yu, Chun-Che Lin, Ming-Yung Lee, James Cheng-Chung Wei*, and Hung-Che Shih. Efficacy and Safety of Herbal Medicine Yun-Cai Tea in the Treatment of Hyperlipidemia: A Double-Blind Placebo-controlled Clinical Trial. Chinese Journal of Integrative Medicine 2013 Feb 28.[Epub ahead of print] (SCI, Impact factor: 1.059Ranking: 12/2157%) *Co-Correspondence

 

13.    James Cheng-Chung Wei, Kuo-Sheng Hung, Yu-Wen Hsu, Ruey-Hong Wong, Chun-Huang Huang, Ming-Shiou Jan, Shyh-Jong Wu, Yung-Shun Juan, Wei-Chiao Chang. Genetic Polymorphisms of Stromal interaction molecule 1 associated with the erythrocyte sedimentation rate and C-reactive protein in HLA-B27 positive ankylosing spondylitis patients. PLoS one 2012 Dec;7(12):e49698. (SCI, Impact factor: 3.730Ranking: 7/5612%)

 

14.    Wu CC, Wei JC, Hsieh CP, Yu CT. Enhanced Healing of Sacral and Pubic Insufficiency Fractures by Teriparatide.J Rheumatol. 2012 Jul;39(6):1306-7.

 

15.    Hui Lin, James Cheng-Chung Wei, Chun-yu Tan, Yuan-yuan Liu, Yan-hong Li, Feng-xia Li, Dai-hua Deng, Bing Yan, Yi Liu, Yi Zhao. Survival analysis of late-onset systemic lupus erythematosus: a cohort study in China. Clin Rheumatol 2012 Dec;31(12):1683-9. DOI 10.1007/s10067-012-2073-6 (SCI, Impact factor: 2.037Ranking:18/2962%)

 

16.    Chang WC, Woon PY, Wei JC, Chang CM, Hsu YW, Guo YC, Hwang DY, Kochi Y, Yen JH. A Single-nucleotide Polymorphism of CCR6 (rs3093024) Is Associated with Susceptibility to Rheumatoid Arthritis But Not Ankylosing Spondylitis, in a Taiwanese Population. J Rheumatol. 2012 Aug;39(8):1765. (SCI, Impact factor: 3.258Ranking: 11/2938%)

 

17.    Shih-Chien Huang, James Cheng-Chung Wei, Ping-Ting Lin, Der Jinn Wu,  Yi-Chia Huang. Plasma pyridoxal 5-phosphate is not associated with inflammatory and immune responses after adjusting for serum albumin in patients with rheumatoid arthritis: a preliminary study. Annals of Nutrition and Metabolism. 2012 Feb;60(2):83-9. (SCI, Impact factor: 2.257Ranking: 33/7445%)

 

18.    Wong RH, Wei JC, Huang CH, Lee HS, Chiou SY, Lin SH, Cai YW, Hung PH, Wang MF, Yang SF. Association of IL-12B Genetic Polymorphism with the Susceptibility and Disease Severity of Ankylosing Spondylitis. J Rheumatol. 2012 Jan;39(1):135-40. Equal contribution to first author. (SCI, Impact factor: 3.258Ranking: 11/2938%)

 

19.    TsungYuan Yang, James ChengChung Wei*, MingYung Lee, C. M. Balance Chen and KwoChang Ueng. A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on anti-hypertensive therapy in Taiwanese patients with uncontrolled hypertension. Phytotherapy Research 2012 Feb;26(2):291-8. (SCI, Impact factor: 2.068Ranking: 145/26056%) *Co-first author.

 

20.    JH Wu, Fiona Leong, JY Chen, CH Huang, ML Tsai, EL Chen, KJ Yeo, JM Cherng, SR Wang, GJ Tsay, PJ Chen, CC Wei. Hepatitis outcome in patients with rheumatic diseases concomitant with chronic hepatitis treated with biological agents. Formosan Journal of Rheumatology 2011;25:35-40 *Correspondence

 

21.    Jaw-Ming Cherng, Kuen-Daw Tsai, Daw-Shyong Perng, Jeng-Shing Wang, Chen