Citizenship:

Office Address

Division of Nephrology, Department of Internal Medicine

Chung Shan Medical University Hospital

No. 110, Sec.1,

Taichung 402,

Telephone: +886-4-24739595 ext 32630

Fax: +886-4-24739595 ext 32624

Education:

1986-1993    M.D., Kaohsiung Medical University

2003~2006   Ph.D., Institute of Medicine , Chung-Shan Medical University

Professional interest:

   kidney transplantation 

   clinical nephrology

   carcinogenesis

   aristolochic acid toxicology

Residency and Fellowship Training:

1993             Medical Resident, Dept. of Internal Medicine, Show-Chwan Memorial Hospital

1994-1996    Medical Resident, Dept. of Internal Medicine, Veterans General Hospital Pu-li

1996-1999    Medical Resident, Dept. of Internal Medicine, Veterans General Hospital Taichung

1999-2001    Chief Resident, Division in Nephrology, Veterans General Hospital Taichung

Board Cirtification

1997~    Society of Internal Medicine

2001~    Society of Nephrology

Academic appointments:

2001~2007       Attending physician, Division of Nephrology, Chung Shan Medical University Hospital

2001~2006       Lecturer, Chung Shan Medical University

2007~2009       Assistant Professor, Chung Shan Medical University

2007~present    Chief, Division of Nephrology, Chung Shan Medical University Hospital

2008.2              Visiting Scholar, Transplant Surgery and Nephrology, Hachioji Medical Center of  Tokyo Medical University,

2009~present    Associate Professor, Institute of Medicine , Chung Shan Medical University

2009~present    Deputy Director of Medical Education, Department of Internal Medicine, Chung Shan Medical University Hospital

Memberships:

1997~present    Taiwan Society of Internal Medicine

2001~present    Taiwan Society of Nephrology,

2001~present    Taiwan Society of Transplantation

2001~present    The Society of Ultrasound in Medicine, R.O.C.

2008~present    Taiwan Society of Urologic Oncology.

Awards

1.          The Transplantation Society Travel Scholarships. 8th congress of the Asian Society of Transplantation. Kuala Lumpur, . 23-27 September 2003  

2.          The Research Award of Journal of the Chinese Medical Association, Taipei , 2004.

3.     The Clinical Research Award of the annual conference of Taiwan Society of Nephrology, 2009.   

Reviewer

1. Life science

2. Clinical Nephrology

3. Acta Nephrologica [Editor]

4. World Journal of Surgery

Research Grant Proposal

1. National Science Council 94-2314-B-040-023: Correlations of the renal function with serum MMPs and  plasminogen activator/inhibitor in renal transplant recipients 2005.08.01 ~ 2006.07.31

2.  National Science Council 95-2314-B-040-012: Correlation of the renal functions with MMPs and plasminogen activator/inhibitor in serum and urine in patients with chronic kidney disease 2006.08.01 ~ 2007.07.31

3.  National Science Council 96-2314-B-040-006-MY2. Study the inhibitory effect and mechanism of silibinin on different renal carcinoma cell (Caki-1, Caki-2, 786-0) invasion and migration 20070801~20090731

4. National Science Council 98-2314-B-040-004-MY3. Study the inhibitory effect on the invasion, induce apoptosis and promote anticancer drug of flavones on different renal carcinoma cells (Caki-1, Caki-2, 786-O). 2009/08/01~2012/07/31

Publications:

1.              Chang HR, Shu KH, Cheng CH, Wu MJ, Chen CH, Lian JD. Peritoneal-Dialysis-Associated Penicillium Peritonitis. American Journal of Nephrology 2000; 20:250-252. (SCI)

2.              Chang HR, Lian JD, Shu KH, Cheng CH, Wu MJ, Chen CH, Lau YJ, Hu BS. Use of Pulsed-Field Gel Electrophoresis in the Analysis of Recurrent Staphylococcus aureus Infections in Patients on Continuous Ambulatory Peritoneal Dialysis. American Journal of Nephrology  2000;20:463-467. (SCI)

3.              Kao CH, Hsieh JF, Tsai SC , Ho YJ, Chang HR. Decreased Salivary Function  in Patients With End-Stage Renal Disease Requiring Hemodialysis. American Journal of Kidney Disease 2000;36:1110-1114. (SCI)

4.              Chang HR, Kao CH, Lian JD, Shu KH, Cheng CH, Wu MJ, Chen CH. Evaluation of the Severity of Traumatic Rhabdomyolysis Using Technetium-99m Pyrophosphate Scintigraphy. American Journal of Nephrology 2001; 21: 208-214. (SCI)

5.              Kao MT, Chang HR, Kao CH, Lin CC, Lee CC. Evaluation of Gallbladder Function in Patients with Non-diabetic Chronic Renal Failure by Quantitative Radionuclide Cholescintigraphy. Hepatogastroenterology 2002;49:613-5. (SCI)

6.              Chang HR, Cheng CH, Shu KH, Chen CH, Lian JD, Wu MJ. Study of the Polymorphism of Angiotensinogen, Angiotensin-Converting Enzyme and Angiotensin Receptor in Type II Diabetes with End-Stage Renal Disease in . Journal of the Chinese Medical Association 2003;66:51-56.

8.              Chang HR, Lian JD, Chan CH, Wong LC. Cytomegalovirus ischemic colitis of a diabetic renal transplant recipient. Clinical Transplantation 2004;18:100-104. (SCI) 

9.              Shu KH, Lan JL, Wu MJ, Cheng CH, Chen CH, Lee WC, Chang HR, Lian JD. Ultralow-dose alpha-interferon plus ribavirin for the treatment of active hepatitis C in renal transplant recipients. Transplantation. 2004;77:1894-1896. (SCI)

10.          Lee CJ, Lian JD, Chang SW, Chou MC, Tyan YS, Wong LC, Chang HR. Lethal Cytomegalovirus Ischemic Colitis Presented with Fever of Unknown Origin. Transplant Infectious Disease. 2004;6:124-128. [Correspondence] (SCI)

11.          Chang HR, Lee MH, Wen MC, Lian JD. Sirolimus addition is beneficial for renal allograft dysfunction due to simultaneous acute rejection episode and calcineurin inhibitor nephrotoxicity. Transplantation proceedings. 2004;36:2668-2670. (SCI)

12.          Chang HR. Post-transplant cytomegalovirus disease presenting with pyloric obstruction. Transplantation. 2005;79:1462-1463. (SCI)

13.          Chang HR, Lin CC, Lian JD. Early experience of enteric-coated mycophenolate sodium in de novo kidney transplant recipients. Transplantation proceedings. 2005;37:2066-2068. (SCI)

14.          Chang HR, Lai CC, Lian JD, Lin CC,Wang CJ^. Formation of 8-nitroguanine in blood of the patients with inflammatory gouty arthritis. Clinica Chimica Acta. 2005, 362: 170-175. (SCI)

15.          Wu MJ, Lian JD, Lee MC, Chang HR, Chen CH, Cheng CH, Shu KH.  Rhabdomyolysis following crush injury in the Taiwan Chi-Chi earthquake. Acta Nephrologica 2005; 19:62-67.

16.          Chang HR, Lian JD, Lo CW, Chang YC, Yang MY, Wang CJ. Induction of Urothelial Proliferation in Rats by Aristolochic Acid through Cell Cycle Progression via Activation of Cyclin D1/Cdk4 and Cyclin E/Cdk2. Food and Chemical Toxicology. 2006;44:28-35. (SCI)

17.          Chang HR, Yang SF, Li ML, Lin CC, Hsieh YS, Lian JD. Relationships between circulating matrix metalloproteinase-2 and -9 and renal function in patients with chronic kidney disease. Clinica Chimica Acta. 2006;366:243-248.  (SCI)

19.          Chan CH, Lee YT, Chang HR, Chan Y, Liu WT. Characterization of various strains of influenza B virus in a neuroblastoma and a glioblastoma cell line. Journal of Microbiology, Immunology and Infection. 2006 Oct;39(5):380-386.

20.          Chang HR, Lian JD, Lo CW, Huang HP, Wang CJ. Aristolochic acid-induced cell cycle G1 arrest in human urothelium SV-HUC-1 cells. Food and Chemical Toxicology. 2007 Mar;45(3):396-402. (SCI)

22.          Hsiao YC, Kuo WH, Chen PN, Chang HR, Lin TH, Yang WE, Hsieh YS, Chu SC.   Flavanone and 2'-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway. Chemico-Biological Interactions. 2007 May; 167(3):193-206. (SCI)

23.          Chang HR, Lin CC, Lian JD. Lack of Hepatotoxicity Upon Sirolimus Addition to a Calcineurin Inhibitor-Based Regimen in Hepatitis Virus-Positive Renal Transplant Recipients. Transplantation proceedings. 2007 Jun; 39(5): 1520-1522. (SCI)

24.          Chang HR, Lin CC, Lian JD. Predictors of renal function improvement following tacrolimus conversion in cyclosporine-treated kidney transplant recipients. Transplantation proceedings. 2007 Dec; 39(10):3142-3148. (SCI)

25.          Hsieh YS, Kuo WH, Lin TW, Chang HR, Lin TH, Chen PN, Chu SC. Protective Effects of Berberine against Low-Density Lipoprotein (LDL) Oxidation and Oxidized LDL-Induced Cytotoxicity on Endothelial Cells. Journal of Agricultural and Food Chemistry. 2007 Dec;55(25):10437-10445. (SCI)

26.          Wen MC, Lian JD, Chang HR, Shu KH, Wu MJ, Chen CH, Jan YJ, Wang J, Chang D. Polyomavirus nephropathy in renal allograft: Prevalence and correlation of histology with graft failure. Nephrology. 2007 Dec;12(6):615-619. (SCI)

27.          Yang SF, Yang WE, Kuo WH, Chang HR, Chu SC , Hsieh YS. Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. Archives of Oral Biology. 2008 Mar;53(3):287-294. (SCI)

28.          Wang SJ, Wang CL, Chang HR, Yang TC. Effect of Parathyroidectomy on Left Ventricular Performance in Hemodialysis Patients by Echocardiographic Evaluation. Acta Nephrologica 2008 Mar; 22(1):41-48.

29.          Chang HR, Kuo WH, Hsieh YS, Yang SF, Lin CC, Lee ML, Lian JD, Chu SC. Circulating matrix metalloproteinase-2 is associated with cystatin C level, post-transplant duration, and diabetes mellitus in kidney transplant recipients. Translational Research 2008 Apr; 151(4):217-223. (SCI)

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