Your browser does not support JavaScript!
分類清單
關宇翔 教授

關宇翔 教授

 (Yu-Hsiang Kuan)

image

 

聯絡電話: 04-24730022 11662

E-mail: kuanyh@csmu.edu.tw

 

學歷: 中山醫學大學醫學研究所 

 現任: 中山醫學大學藥理學科 教授 

 經歷: 中山醫學大學醫學系藥理科副教授 

     中山醫學大學醫學系藥理科助理教授 

            樹人醫護管理專校視光科助理教授

           成功大學醫學院博士後研究員 

 

專長: 免疫藥理、基因毒性、神經藥理、細胞訊息傳遞、開發保健食品與新藥

 

研究:1. 開發新藥、傳統中草藥或保健食品的抗發炎、抗氧化、抗衰老的作用,及其作用機制。

 

2. 開發新藥、傳統中草藥或保健食品用於降低肺部疾病的作用與機制。

 

3. 開發新藥、傳統中草藥或保健食品用於基因毒性相關研究與作用機制。

 

4. 開發新藥、傳統中草藥或保健食品用於神經元、神經膠細胞相關保護作用的研究與作用機制。

 

5. 開發新藥、傳統中草藥或保健食品用於海馬迴細組織相關保護作用的研究與作用機制。

 

6. 開發新藥、傳統中草藥或保健食品用於阿茲海默症相關保護作用的研究與作用機制。

 

期刊論文 (皆為 SCI 期刋)                            (* 通訊作者)

1. Chen WY, Huang YC, Yang ML, Lee CY, Chen CJ, Yeh CH, Pan PH, Horng CT, Kuo WH, Kuan YH*. Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation. Int Immunopharmacol 2014 (SCI, IF = 2.711) (PHARMACOLOGY & PHARMACY, Ranking: 95/254 = 37.40%).

2. Huang FM, Chang YC, Lee SS, Yeh CH, Lee KG, Huang YC, Chen CJ, Chen WY, Pan PH, Kuan YH*. BisGMA-induced cytotoxicity and genotoxicity in macrophages are attenuated by wogonin via reduction of intrinsic caspase pathway activation. Environ Toxicol. 2014. (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%)

3. Huang YC, Horng CT, Chen ST, Lee SS, Yang ML, Lee CY, Kuo WH, Yeh CH, Kuan YH*. Rutin improves endotoxin-induced acute lung injury via inhibition of iNOS and VCAM-1 expression. Environ Toxicol. 2014. (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%)

4. Lee CY, Yang JJ, Lee SS, Chen CJ, Huang YC, Huang KH, Kuan YH*. Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via JNK- and Akt-dependent NFκB pathway. J Agric Food Chem. 2014 (SCI, IF=3.107) (AGRICULTURE, MULTIDISCIPLINARY Ranking: 2/56 = 3.57%)

5. Li TC, Kuan YH, Ko TY, Li C, Yang JJ. Mechanism of a novel missense mutation, p.V174M, of the human connexin31 (GJB3) in causing nonsyndromic hearing loss. Biochem Cell Biol. 2014 May 15 ;92(4):251-7. (SCI, IF=2.350) (BIOCHEMISTRY & MOLECULAR BIOLOGY Ranking: 182/291 = 62.54 %)

 6. Chang CY#, Kuan YH# Ou YC, Li JR, Wu CC, Pan PH, Chen WY, Huang HY, Chen CJ. Autophagy contributes to gefitinib-induced glioma cell growth inhibition. Exp Cell Res. 2014 May 27. pii: S0014-4827(14)00202-X. doi: 10.1016/j.yexcr.2014.05.011. (SCI, IF=3.372) (ONCOLOGY Ranking: 77/202 = 35.15%)

 7. Ou YC, Li JR, Kuan YH, Raung SL, Wang CC, Hung YY, Pan PH, Lu HC, Chen CJ. Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis. Life Sci. 2014; 100: 110-117. (SCI, IF=2.296) (PHARMACOLOGY & PHARMACY Ranking: 124/254= 48.81%)

8. Yeh CH, Yang JJ, Yang ML, Li YC, Kuan YH*. Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK-NF-κB pathway. Free Radic Biol Med. 2014; 69C: 249-257. (SCI, IF=5.71) (Endocrinology, Diabetes and Metabolism, Ranking 15/123 =12.19%)

 9. Kuan YH#, Huang FM#, Lee SS, Li YC, Chang YC*. BisGMA stimulates prostaglandin E2 production in macrophages via cyclooxygenase-2, cytosolic phospholipase A2, and mitogen-activated protein kinases family. PLoS One 2013; 8: e82942. (SCI, IF=3.534) (MULTIDISCIPLINARY SCIENCES, Ranking 8/55 =14.54%) (# These authors contributed equally to this work)

 10. Hung CJ, Wu CC, Chen WY, Chang CY, Kuan YH, Pan HC, Liao SL, Chen CJ*. Depression-like effect of prenatal buprenorphine exposure in rats. PLoS One. 2013; 8: e82262. (SCI, IF=3.534) (MULTIDISCIPLINARY SCIENCES, Ranking 8/55 =14.54%)

 11. Huang FM, Kuan YH, Lee SS, Chang YC*. Cytotoxicity and Genotoxicity of Triethyleneglycol- Dimethacrylate in Macrophages Involved in DNA Damage and Caspases Activation. Environ Toxicol. 2013. (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%).

 12. Chang CY#, Kuan YH#, Li JR, Chen WY, Ou YC, Pan HC, Liao SL, Raung SL, Chang CJ, Chen CJ*. Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. J Nutr Biochem 2013; 24: 2127-37. (SCI, IF=4.592) (NUTRITION & DIETETICS, Ranking 9/78 =11.53 %) (#These authors contributed equally to this work)

 13. Lin RH, Yang ML, Li YC, Kuan YH*. Indium chloride-induced micronuclei via reactive oxygen species in Chinese hamster lung fibroblast V79 cells. Environ Toxicol. 2013; 28: 595-600 (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%)

 14. Liao SL, Ou YC, Chang CY, Chen WY, Kuan YH, Wang WY, Pan HC, Chen CJ. Diethylmaleate and iodoacetate in combination caused profound cell death in astrocytes. J Neurochem. 2013; 127: 271-82 (SCI, IF = 4.244) (NEUROSCIENCES, Ranking: 63/251 = 25.10%)

 15. Kao TK, Chang CY, Ou YC, Chen WY, Kuan YH, Pan HC, Liao SL, Li GZ, Chen CJ*. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013; 247:188-201. SCI, IF = 4.617) (NEUROSCIENCES, Ranking: 53/251 = 21.15%)

 16. Yeh CH, Shih HC, Hong HM, Lee SS, Yang ML, Chen CJ, Kuan YH*. Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. (In press). Toxicol Ind Health. 2013. (SCI, IF = 1.710) (PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH , Ranking: 76/160 = 47.5%)

17. Yeh CH, Yang ML, Lee CY, Yang CP, Li YC, Chen CJ, Kuan YH*. Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells (In press). Environ Toxicol. 2013 (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%)

 18. Ou YC, Kuan YH, Cheng CL, Ruang SL, Wang CC, Huang YY, Chen CJ*. Induction of apoptosis by luteolin involving Akt inactivation in human 786-O renal cell carcinoma cells. Evid Based Complement Alternat Med. 2013; 2013: 109105 (SCI, IF =2.175) (INTEGRATIVE & COMPLEMENTARY MEDICINE, Ranking: 6/22=27.27%)

 19. Lee SS, Tsai CH, Kuan YH, Huang FM, Chang YC*.The upregulation of transglutaminase-2 by cyclosporine A in human gingival fibroblasts is augmented by oxidative stress. J Periodontol. 2013; 84:1469-75. (SCI, IF = 2.565) (DENTISTRY, ORAL SURGERY & MEDICINE, Ranking: 12/82=14.63%)

20. Li YC, Kuan YH, Lee TH, Huang FM, Chang YC*. Assessment of the cytotoxicity of chlorhexidine by employing an in vitro mammalian test system. J Dent Sci. 2013 (In press) (SCI, IF = 0.465) (DENTISTRY, ORAL SURGERY & MEDICINE, Ranking: 77/82=93.90%)

 21. Huang CH, Yang ML, Tsai CH, Lin YC, Lin YJ, Kuan YH*. Ginkgo biloba leaves extract (EGB 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-kB-dependent matrix metalloproteinase-9 pathway. Phytomedicine. 2013; 20: 303-9 (SCI, IF = 2.877) (INTEGRATIVE & COMPLEMENTARY MEDICINE, Ranking: 2/22=9.09%)

 22. Kuan YH, Huang FM, Li YC, Chang YC*. Proinflammatory activation of macrophages by bisphenol A-glycidyl-methacrylate involved NFκB activation via PI3K/Akt pathway. Food Chem Toxicol. 2012;50:4003-9. (SCI, IF = 2.610) (FOOD SCIENCE & TECHNOLOGY, Ranking: 21/123=17.07%)

 23. Li YC, Kuan YH, Lee SS, Huang FM, Chang YC*. Cytotoxicity and Genotoxicity of Chlorhexidine on Macrophages In Vitro. (In press) Environ Toxicol. 2014; 29(4): 452-8 (SCI, IF = 2.562) (WATER RESOURCES, Ranking: 14/79 = 17.72%)

 24. Kuan YH, Li YC, Huang FM, Chang YC*. The upregulation of tumor necrosis factor-α and surface antigens expression on macrophages by bisphenol A-glycidyl-methacrylate. Int Endod J. 2012;45:619-26 (SCI, IF = 2.322) (DENTISTRY, ORAL SURGERY & MEDICINE, Ranking: 16/82=19.52%)

 25. Li YC, Kuan YH, Huang FM, Chang YC*. The role of DNA damage and caspases activation in cytotoxicity and genotoxicity of macrophages induced by bisphenol-A-glycidyldimethacrylate. Int Endod J. 2012;45:499-507 (SCI, IF = 2.322) (DENTISTRY, ORAL SURGERY & MEDICINE, Ranking: 16/82=19.52%)

 26. Li YC, Yeh CH, Yang ML, Kuan YH*. Luteolin suppresses inflammatory mediator expression by blocking the Akt/NFκB pathway in acute lung injury induced by lipopolysaccharide in mice. Evid Based Complement Alternat Med. 2012;2012:383608. (SCI, IF =2.175) (INTEGRATIVE & COMPLEMENTARY MEDICINE, Ranking: 6/22=27.27%)

27. Liao PH, Lin RH, Yang ML, Li YC, Kuan YH*. Evaluation of differential representative values between Chinese hamster cells and human lymphocytes in mitomycin C-induced cytogenetic assays and caspase-3 activity. Toxicol Ind Health. 2012;28:174-80. (SCI, IF = 1.710) (PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH , Ranking: 76/160 = 47.5%)

 28. Kuo MY, Liao MF, Chen FL, Li YC, Yang ML, Lin RH, Kuan YH*. Luteolin attenuates the pulmonary inflammatory response in mice with endotoxin-induced acute lung injury which involves antioxidation and inhibition of MAPK and NFκB pathways. Food Chem Toxicol. 2011; 49(10): 2660-6. (SCI, IF = 2.610) (FOOD SCIENCE & TECHNOLOGY, Ranking: 21/123=17.07%)

 29. Liao PH, Hung LM, Chen YH, Kuan YH, Zhang FB, Lin RH, Shih HC, Tsai SK, Huang SS*. Cardioprotective effects of luteolin during ischemia-reperfusion injury in rats. Circ J. 2011;75(2):443-50. (SCI, IF = 3.685) (CARDIAC & CARDIOVASCULAR SYSTEMS, Ranking: 36/125-28.8%)

30. Lee MY#, Kuan YH#, Chen HY, Chen TY, Chen ST, Huang CC, Yang IP, Hsu YS, Wu TS, Lee EJ*. Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. J Pineal Res. 2007; 42(3): 297-309 (SCI, IF = 5.794) (PHYSIOLOGY, Ranking: 5/79=6.32%) (# These authors contributed equally to this work)

 31. Kuan YH, Lin RH, Chen YL, Tsao LT, Tzeng CC, Wang JP*. Effective attenuation of neutrophil influx in acute lung injury in vivo and the formyl peptide-induced neutrophil activation in vitro by CYL-26z through the phosphoinositide 3-kinase g pathway. Biochem Pharmacol 2006; 72: 749-760. (SCI; IF = 4.705) (PHARMACOLOGY & PHARMACY, Ranking: 28/261= 10.72%)

 32. Kuan YH, Lin RH, Lin HY, Huang LJ, Tsai CR, Tsao LT, Lin CN, Chang LC, Wang JP*. Activation of phosphoinositide 3-kinase and Src family kinase is required for respiratory burst in rat neutrophils stimulated with artocarpol A. Biochem Pharmacol 2006; 71: 1735-1746. (SCI; IF = 4.705) (PHARMACOLOGY & PHARMACY, Ranking: 28/261= 10.72%)

 33. Kuan YH, Lin RH, Tsao LT, Chen YL, Tzeng CC, Wang JP*. Inhibition of phospholipase D activation by CYL-26z in formyl eptide-stimulated neutrophils involves the blockade of RhoA activation. Biochem Pharmacol 2005; 70: 901-910. (SCI; IF = 4.705) (PHARMACOLOGY & PHARMACY, Ranking: 28/261= 10.72%)

 34. Kuan YH, Lin RH, Tsao LT, Lin CN, Wang JP*. Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways. Brit J Pharmacol 2005; 145: 460-468. (SCI; IF = 4.409) (PHARMACOLOGY & PHARMACY, Ranking: 35/261 =13.41%)

 35. Wang JP*, Chang LC, Kuan YH, Tsao LT, Huang LJ, Kuo SC.  2-Benzyloxybenzaldehyde inhibits formyl peptide-stimulated increase in intracellular Ca2+ in neutrophils mainly by blocking Ca2+ entry. N-S Arch Pharmacol 2004; 370: 353-360. (SCI; IF = 2.647) (PHARMACOLOGY & PHARMACY, Ranking: 101/261 = 38.70%)

 36. Hsu MF, Lu MC, Tsao LT, Kuan YH, Chen CC, Wang JP*. Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Biochem Pharmacol 2004; 67:831-840. (SCI; IF = 4.705) (PHARMACOLOGY & PHARMACY, Ranking: 28/261= 10.72%)

 

會議論文

 

1. Lin YR, Lee SS, Kuan YH*. Okadaic acid induced nitric oxide (NO) and prostaglandin E2 (PGE2) via Akt-NFkB pathway. Annual Conference of Biomedical Sciences. 2014; Post. (Taipei, Taiwan)

 2. Kuan YH, Lee SS, Lin YR*. Brevetoxin induced nitric oxide (NO) and prostaglandin E2 (PGE2) via Akt-NFkB pathway. Annual Conference of Biomedical Sciences. 2014; Post. (Taipei, Taiwan)

 3. Tseng CC, Lee SS, Kuan YH, Sheu GT. Cytotoxicity and genotoxicity of macrophages induced by 1-Nitropyrene pathway. Annual Conference of Biomedical Sciences. 2014; Post. (Taipei, Taiwan)

 4. Lin YR, Lee SS, Kuan YH*. The generation of proinflammatory mediators on macrophages by Okadaic acid. Annual Conference of Biomedical Sciences. 2013; P.481. (Taipei, Taiwan)

 5. Kuan YH, Lee SS, Lin YR*. The generation of proinflammatory mediators on macrophages by Brevetoxin. Annual Conference of Biomedical Sciences. 2013; P.992. (Taipei, Taiwan)

 6. Chang YC, Lin RH, Liao PH, Kuan YH*, Li YC. Chinese hamster lung fibroblasts (V79) more suitably act as a predictor of cytogenetic assays than human lymphocytes. Annual Conference of Biomedical Sciences. 2012; P.476. (Taipei, Taiwan)

 7. Lee SS, Chang CW, Chen FY, Tsai SC, Yang ZY, Chen JS, Kuan YH*, Li YC. Mechanisms of cytotoxicity of XH-1 employing in vitro mammalian test system Annual Conference of Biomedical Sciences. 2012; P.477. (Taipei, Taiwan).

 8. Chen HL, Yang ML, Liao PH, Lin RH, Kuan PC, Liao MF, Li YC, Kuan YH*. Evaluation of mitomycin C induced genotoxic damage in Chinese hamster cells and human lymphocytes. The 23rd Federation of Asian Pharmaceutical Associations Congress. 2011; 190 (Taipei, Taiwan).

 9. Chen HL, Li YC, Kuan YH*. Protect effect of luteolin against lipopolysaccharide-induced acute lung injury: inhibits MEK/ERK and PI3K/Akt pathway in neutrophil. The 23rd Federation of Asian Pharmaceutical Associations Congress. 2010; 189 (Taipei, Taiwan).

 10. Tou LC, Shih MW, Li YC, Kuan YH*. Luteolin attenuates acute lung injury in lipopolysaccharide-treated mice via treated mice via the MAPK and NFκB pathways. The 23rd Federation of Asian Pharmaceutical Associations Congress. 2010; 291 (Taipei, Taiwan).

11. Lee EJ*, Huang SY, Kuan YH, Chen TY, Chen HY, Wu TS. Electrophysiological evidence for long-term depression in the contralateral, intact brain following transient focal cerebral ischemia in rats. The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function (Brain’07) and the 8th International Conference on Quantification of Brain Function with PET (BrainPET’07). 2007; BP18-5W (Osaka, Japan)

12. Chen TY, Kuan YH, Chen HY, Lee MY, Lee EJ*. Nicotinamide reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. Nicotinamide reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function (Brain’07) and the 8th International Conference on Quantification of Brain Function with PET (BrainPET’07). 2007; BP7-6M (Osaka, Japan)

 

13. Chen HY, Chen TY, Huang CC, Kuan YH, Lee EJ*, Wu TS. Cinnamophilin attenuates gray and white matter damage and improves neurobehavioral and electrophysiological recoveries following transient focal cerebral ischemia. The 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function (Brain’07) and the 8th International Conference on Quantification of Brain Function with PET (BrainPET’07). 2007; BP8-7U (Osaka, Japan)

 

14. Lin YC, Chen HY, Lee EJ, Kuan YH, Chuang IC*. The protective efficacy of magnolol in hind limb muscular ischemia reperfusion injury. 嘉南藥理科技大學藥理學院師生研究發表會. 2007; B-35 (Tainan, Taiwan)

 15. Chen HY*, Kuan YH, Ke SW, Xu JY, Lo KW, Lee EJ. Wu TS. Cinnamophilin reduces oxidative damage and project against transt transient focal cerebral ischemia in mice. Annual Conference of Pharmaceutical Society of Taiwan. 2006; P. 387  (Taichung, Taiwan)

 16. Lee MY#, Kuan YH#, Chen HY, Lee WT, Yu SQ, Huang SY, Tsao ZJ, Lo KW, Lee EJ*. The neuroprotective effects of nicotinamide against excitotoxicity in primary neuronal culture. Annual Conference of NCKU Research Project. 2006; P.45 (# These authors contributed equally to this work) (Tainan, Taiwan)

 17. Kuan YH, Lee MY, Chen HY, Chen TY, Chen ST, Huang CC, Yang IP, Hsu YS, Wu TS, Lee EJ*. Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. International Conference on Cerebrovascular Surgery. 2006; P46. (Taipei, Taiwan)