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分類清單
黃相碩 教授兼主任

 

黃相碩  教授

Shiang-Suo Huang Ph. D

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 聯絡方式:

 

電話: 04-24730022轉11665

 

mail: sshuang@csmu.edu.tw

 

學歷:國立台灣大學醫學院藥理所博士

  

經歷: 台北榮總傳統醫學研究中心副研究員

             臺大醫學院麻醉部博士後研究員

            台灣大學醫學院藥理科助教 

  

現任:藥理學科教授

  

專長:心血管疾病,藥理學,生理學

 

研究:1. 傳統中草藥的抗氧化活性的評估,藥理藥效及其作用機轉探討。

   

            2. 心肌梗塞活體動物實驗模式之病理生理機轉研究。

   

3. 中風活體動物模式之病理生理機轉。

  

4. 探討缺血/再灌注的活體動物模式中一氧化氮在保護作用中所扮演的角色。

   

5. 探討缺血/再灌注的活體動物模式中基因表現的改變以及化合物的保護作用與基因表現的相關性。

   

6. 探討抗發炎作用在缺血/再灌注的活體動物模式中所扮演的角色。

  

           7. Bone marrow以及生長因子對於神經再生的作用,評估其在中樞缺血/再灌注動物模式中的作用。

    

8. 化合物的神經電生理作用機轉研究。

   

9. 化合物對於平滑肌作用機轉研究。

   

10. 化合物在軟體動物的食道下神經節作用機轉研究。

    

(A) REFEREED PAPER  

 

1.          Tsai M.J., Tsai S.K., Hu B.R., Liou D.Y., Huang S.L., Ming-Chao Huang M.C., Huang W.C., Cheng H., Huang S.S. (2014) Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats. J Biomed Sci. 22;21:5. (IF=2.458; MEDICINE, RESEARCH & EXPERIMENTAL)

 

2.          Huang S.S., Lu Y.J., Huang J.P., Wu Y.T., Day Y.J., Hung L.M. (2014) The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. J Vasc Surg 59: 483-491. (IF=2.879; SURGERY; 24/198=12.12%) (NSC-100- 2320-B-040-007).

 

3.          Lin H.Y., Huang B.R., Yeh W.L., Lee C.H., Huang S.S., Lai C.H., Lin H., Lu D.Y. (2014) Anti-neuroinflammatory effects of lycopene via activation of AMPK<alpha>1/HO-1 pathways. Neurobiol Aging 35(1): 191-202 (IF=6.166; NEUROSCIENCES; 28/251=11.16%)

 

4.          Huang S.S., Cheng H., Tang C.., Nien M.W., Huang Y.S., Lee I.H., Yin J.H., Kuo T.B., Yang C.C., Tsai S.K., Yang D.I. (2013) Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Exp Neurol 247: 680-688. (IF=4.645; NEUROSCIENCES; 48/251= 19.12%.)

 

5.          Chen Y.S., Chen S.D., Wu C.L., Huang S.S., Yang D.I. (2013) Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture. Exp Neurol (In press) (IF=4.645; NEUROSCIENCES; 48/251=19.12%.)

 

6.          Lin Y. K., Chen Y.C. Huang J.H., Lin Y.J., Huang S.S., Chen S.A., Chen Y.J. (2013) Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. J Biomed Sci. 20;20:94. (IF=2.458; MEDICINE, RESEARCH & EXPERIMENTAL)

 

7.          Lu D.Y., Huang B.R., Yeh W.L., Lin H.Y., Huang S.S., Liu Y.S., Kuo Y.H. (2013) Anti-neuroinflammatory effect of a novel caffeamide derivative, KS370G, in microglial cells. Mol Neurobiol 48(3): 863-874 (IF=5.471; NEUROSCIENCES; 37/251=14.74%)

 

8.          Huang B.R., Tsai C.F., Lin H.Y., Tseng W.P., Huang S.S., Wu C.R., Lin C., Yeh W.L., Lu D.Y. (2013) Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid. Toxicol Appl Pharmacol 269(1): 43-50 (IF=3.975; PHARMACOLOGY & PHARMACY; 44/260=16.92%)

 

9.          Huang S.S., Su H.H., Kuo T.B., Chen C.Y., Lan Y.Y., Liu B.Y., Yang D.I., Tsai S.C., Yang C.C. (2012) Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Auton. Neurosci-Basic Clin 169(2): 116-123 (IF=1.846; NEUROSCIENCES; 187/251=74.50%)

 

10.      Ho YJ, FL Chen, SM Liu, AL Wang, YC Li, TJ Lai, SS Huang*. (2012) Effects of chronic resistive airway loading on behavioral changes in rats. Chin J Physiol 55(4): 245-252. (IF=0.748; PHYSIOLOGY)

 

11.      Lin J.F., Wu S., Huang S.S., Lu B.Y., Lin S.M., Tsai S.K. (2011) Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction. Chin J Physiol. 54(6): 406-412. (IF=0.748; PHYSIOLOGY)

 

12.      Su T.R., Hung Y.S., Huang S.S., Su H.H., Su C.C., Hsiao G., Chen Y.H., Lin M.J. (2011) Study of the reversal effect of NF449 on neuromuscular blockade induced by d-tubocurarine. Life Sciences 88: 1039-1046. (IF=2.555; PHARMACOLOGY & PHARMACY; 107/260=41.15%)

 

13.      Liao P.H., Hung L.M., Chen Y.H., Kuan Y.H., Zhang F.B.Y., Lin R.H., Shih H.C., Tsai S.K., Huang S.S.* (2011) Cardioprotective effects of luteolin during ischemia/reperfusion injury in rats. Circulation Journal, 75: 443-450. (corresponding author) (IF=3.578; CARDIAC & CARDIOVASCULAR SYSTEMS ; 32/122=26.23%) (97-2320-B-040- 003)

 

14.      Huang J.P., Huang S.S., Deng J.Y., Day Y.J. Hung L.M. (2010) Insulin and resveratrol act synergistically preventing cardiac dysfunction in diabetes but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. Free Radical Biology and Medicine 49: 1710-1721. (Huang JP and Huang SS contributed equally to this work) (IF: 5.271; ENDOCRINOLOGY & METABOLISM; 17/121=14.05%)

 

15.      Hsieh Y.H., Huang S.S., Day Y.J., Wei F.C. Hung L.M. (2010) Involvement of YC-1 in Extracellular Signal-Regulated Kinases action really interesting in cremasteric muscle. Journal of Pharmacy and Pharmacology, 62: 1746-1752. (Hsieh YH and Huang SS contributed equally to this work) (IF: 2.033; PHARMACOLOGY & PHARMACY; 148/260=56.92%)

 

16.      Chen Y.H., Lin P.L., Hsu H.Y., Wu Y.T., Yang H.Y., Lu D.Y., Huang S.S., Hsieh C.L., Lin J.G. (2010) Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents. Acta Pharmacologica Sinica 31: 1553-1563. (IF=2.354; CHEMISTRY, MULTIDISCIPLINARY; 50/152=32.89%)

 

17.      Chen S.J., Chang C.M., Tsai S.K., Chang Y.L., Chou S.J., Huang S.S., Tai L.K., Chen Y.C., Ku H.H., Li H.Y., Chiou S.H. (2010) Functional Improvement of Focal Cerebral Ischemia Injury by Subdural Transplantation of Induced Pluripotent Stem Cells with Fibrin Glue. Stem cells and development 19: 1757-1767. (IF=4.670; TRANSPLANTATION; 3/26=11.54%)

 

18.      Lin P.L., Tsai M.C., Lu G.L., Lu D.Y., Chuang C.M., Yang H.Y., Huang S.S., Chen Y.H. (2010) Ecstasy and methamphetamine elicit action potential bursts via different mechanisms in a central snail neuron. NeuroToxicology 31: 26-41. (IF=2.652; PHARMACOLOGY & PHARMACY; 100/260=38.46%)

 

19.      Huang J.P., Huang S.S., Deng J.Y., Hung L.M. (2009) Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats. Journal of Biomedical Science 16:77. (Huang JP and Huang SS contributed equally to this work). (IF=2.458; MEDICINE, RESEARCH & EXPERIMENTAL)

 

20.      Yang C.Y., Ho Yi. Cheng., Pang J.C., Huang S.S., Tschen J.S.M. (2009) Cloning and expression of an antifungal chitinase gene of a novel Bacillus subtilis isolate from Taiwan potato field. Bioresource Technology 100(3):1454-1458. (IF=4.750; AGRICULTURAL ENGINEERING; 1/12=8.33%)

 

21.      Lin J.F., Lin S.M., Chih C.L., Nien M.W., Su H.H., Hu B.R., Huang S.S.*, Tsai S.K. (2008) Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats. Life Sciences 83(9-10):313-317. (corresponding author) (IF=2.555; PHARMACOLOGY & PHARMACY; 107/260=41.15%) (NSC-95- 2320-B-040-027).

 

22.      Tsai S.K., Hung L.M., Fu Y.T., Cheng H., Nien M.W., Liu H.Y., Zhang F.B.Y., Huang S.S.* (2007) Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. J. Vasc. Surg. 46: 346-353. (corresponding author) (IF=2.879; SURGERY; 24/198=12.12%.) (NSC-94-2320-B-040-028).

 

23.      Hsieh Y.H., Huang S.S., Wei F.C. Hung L.M.* (2007) Resveratrol attenuates ischemia-reperfusion induced leukocyte-endothelial cell adhesive interactions and prolongs allograft survival across MHC barrier. Cir. J. 71: 423-428. (Hsieh YH and Huang SS contributed equally to this work). (IF=3.578; CARDIAC & CARDIOVASCULAR SYSTEMS ; 32/122=26.23%)  (NSC-95-2320-B-040-027).

  

 

(B) CONFERENCE PAPER

  

Lin S.M., Tsai S.K., Chih C. L., Nien M.W., Huang S.S., 2012 Wogonin reduces infarct size and improves ventricular function in chronic myocardial ischemia rats. Experimental Biology 2012, Harbor Drive, San Diego, California, USA.

 

Lee I.H., Liao K.H., Chuang C.Y., Huang S.S., Chuang C.C., Lin H.J., Hsieh J.Y., Su Y.S., Su S.H., Lee O.K.S., Kuo H.C., Wang H.W., 2010 Human iPS cells-derived neural progenitors exhibit preferential neuroprotection for stroke via a unique secretome. Neuroscience 2010, San Diego, CA, USA.

 

Lu Y.J., Huang S.S., Hung L.M., 2009 Hyperglycemia attenuates Akt/eNOS phosphorylations and aggravates cerebral ischemia-reperfusion injury in STZ-induced diabeteic rats. The 36th Congress of the International Union of Physiological Sciences (IUPS2009), Kyoto, Japan.

 

Yang C.Y., Zhang F.B.Y., Chen J.H., Chang J.H., Chien S.H., Liao P.H., Lin R.H., Huang S.S., 2007 Aqueous Extract From Antrodia camphorata (BCRC-930032) Protects Rat Heart Against Ischemia and Ischemia–Reperfusion Injury. The 22th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.

 

Liu S.M., Lai M.N., Chang C.H., Hsieh H.Y., Liu H.Y., Huang S.S., 2007 Antiarrhythmic effects of antrodia cinnamomea (AC-2) on rats subjected to myocardial ischemia and ischemia-reperfusion injury. The 21th Joint Annual Conference of Biomedical Science, Taipei, R.O.C.