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分類清單
黃相碩 教授兼主任

 

 

黃相碩  教授

Shiang-Suo Huang Ph. D

   

聯絡方式:

 

電話: 04-24730022轉11665

 

mail: sshuang@csmu.edu.tw

 

學歷:國立台灣大學醫學院藥理所博士

 

經歷: 台北榮總傳統醫學研究中心副研究員

             臺大醫學院麻醉部博士後研究員

             台灣大學醫學院藥理科助教 

  

現任:藥理學科教授

  

專長:心血管疾病,藥理學,生理學

 

研究:

  1. 傳統中草藥的抗氧化活性的評估,藥理藥效及其作用機轉探討。

  2. 心肌梗塞活體動物實驗模式之病理生理機轉研究。

  3. 中風活體動物模式之病理生理機轉。

  4. 探討缺血/再灌注的活體動物模式中一氧化氮在保護作用中所扮演的角色。

  5. 探討缺血/再灌注的活體動物模式中基因表現的改變以及化合物的保護作用與基因表現的相關性。

  6. 探討抗發炎作用在缺血/再灌注的活體動物模式中所扮演的角色。

  7. Bone marrow以及生長因子對於神經再生的作用,評估其在中樞缺血/再灌注動物模式中的作用。

  8. 化合物的神經電生理作用機轉研究。

  9. 化合物對於平滑肌作用機轉研究。

  10. 化合物在軟體動物的食道下神經節作用機轉研究。 

 

 

三年內執行之研究計畫

 

計畫名稱

計畫內擔任之工作

起迄年月

補助或委託機構

執行情形

探討GDF11對抗缺血性中風傷害的神經保護作用

主持人

2017/08/01~

2018/07/31

科技部

執行中

評估Smad2/3訊息傳遞在GDF11保護心臟對抗缺血再灌注傷害之心臟保護作用中所扮演的角色

共同主持人

2017/08/01~

2018/07/31

科技部

執行中

利用大鼠探討睡眠後期心血管事件發生之危險因子、機轉及預防:異常交感神經及血壓的驟升

共同主持人

2016/08/01~

2019/07/31

科技部

執行中

可溶性環氧化合物水解酶之腦傷研究-(子計畫二)可溶性環氧化合物水解酶對腦中風後神經可塑性的影響機制

共同主持人

2016/08/01~

2017/07/31

科技部

已結案

探索乙苯胺醯衍生物作為Kv7蛋白激活劑其結構-活性相關性之藥理分析

主持人

2016/08/01~

2017/07/31

科技部

已結案

可溶性環氧化合物水解酶之腦傷研究-(子計畫二)可溶性環氧化合物水解酶對腦中風後神經可塑性的影響機制(2/3)

共同主持人

2015/08/01~

2016/07/31

科技部

已結案

新開發的N-(2-ethylphenyl)bicycle- heptane-2-carboxamide其做為KCNQ蛋白開啟劑藥理作用之探討與其可能的醫學應用

主持人

2015/08/01~

2016/10/31

科技部

已結案

評估GDF11對抗心肌缺血再灌注傷害之心臟保護作用

共同主持人

2015/08/01~

2017/07/31

科技部

已結案

可溶性環氧化合物水解酶之腦傷研究-(子計畫二)可溶性環氧化合物水解酶對腦中風後神經可塑性的影響機制(1/3)

共同主持人

2014/08/01~

2015/07/31

科技部

已結案

抗發炎機制在於Lumbrokinase心臟保護作用中扮演的角色

主持人

2014/08/01~

2017/07/31

科技部

已結案

 

 

REFEREED PAPER  

 

 

1. Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH. (2017, Dec). Blockade of Soluble Epoxide Hydrolase Attenuates Post-ischemic Neuronal Hyperexcitation and Confers Resilience Against Stroke with TrkB Activation. Sci Rep., In press.

 

2. Su HH, Chu YC, Liao JM, Wang YH, Jan MS, Lin CW, Wu CY, Tseng CY, Yen JC, Huang SS*. (2017, Apr). Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation. Front Pharmacol. 8:175. MOST103-2320-B-040-001-MY3.

 

3. Chavez LM, Huang SS, MacDonald I, Lin JG, Lee YC, Chen YH (2017, Oct). Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies. Int J Mol Sci. 18(11): 2270.

 

4. Hung YC, Kuo YJ, Huang SS, Huang TF. (2017, Oct). Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function. Eur J Pharmacol. 813:24-32 . MOST 103-2320-B-040-001-MY3.

 

5. Yang CCH, Huang SS, Lai CT, Kuo TBJ, Chu YC (2017, Jun). Changes in Sleep Architecture under Sustained Pain in Adult Male Rats Subjected to Neonatal Short-Lasting Local Inflammatory Insult. Dev Neurosci. 39(5):386-98.

 

6. Lee IH, Huang SS, Chuang CY, Liao KH, Chang LH, Chuang CC, Su YS, Lin HJ, Hsieh JY, Su SH, Lee OK, Kuo HC. (2017, May). Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke. Sci Rep. 7:1943. MOST104-2320-B-075-001.

 

7. Wang YH, Chen KM, Chiu PS, Lai SC, Su HH, Jan MS, Lin CW, Lu DY, Fu YT, Liao JM, Chang JT, Huang SS*. (2016, Aug). Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling. J Mol Cell Cardiol., 2016;99:113-22. MOST103-2320-B-040-001-MY3

 

8. Tsai HJ, Huang SS, Tsou MT, Wang HT, Chiu JH. (2015, Oct). Role of Opioid Receptors Signaling in Remote Electrostimulation--Induced Protection against Ischemia/Reperfusion Injury in Rat Hearts. PLoS One, 10(10):e0138108.

 

9. Tsai MJ, Tsai SK, Huang MC, Liou DY, Huang SL, Hsieh WH, Huang WC, Huang SS*, Cheng H. (2015, Oct). Acidic FGF promotes neurite outgrowth of cortical neurons and improves neuroprotective effect in a cerebral ischemic rat model. Neuroscience 305:238-47. MOST103-2320-B-040-001-MY3.

 

10. Li IH, Ma KH, Weng SJ, Huang SS, Liang CM, Huang YS. (2014, Dec). Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons. PLoS One, 31;9(12):e116565.

 

11. Hung LM, Huang JP, Liao JM, Yang MH, Li DE, Day YJ, Huang SS*. (2014, Sep). Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite. J Biomed Sci. 21:92. NSC100-2320-B-040 -007.

 

12. Huang SS, Yan YH, Ko CH, Chen KM, Lee SC, Liu CT. (2014, Jul). A Comparison of Food-grade Folium mori ( Sāng Ye) Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocininduced Diabetic Rats. J Tradit Complement Med. 4(3):162-70.

 

13. Hsieh WT, Yeh WL, Cheng RY, Lin C, Tsai CF, Huang BR, Wu CY, Lin HY, Huang SS, Lu DY. (2014, Jun). Exogenous endothelin-1 induces cell migration and matrix metalloproteinase expression in U251 human glioblastoma multiforme. J Neurooncol. 118(2):257-69.

 

14. Huang BR, Chang PC, Yeh WL, Lee CH, Tsai CF, Lin C, Lin HY, Liu YS, Wu CY, Ko PY, Huang SS, Hsu HC, Lu DY. (2014, Mar). Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One, 9(3):e91167.

 

15. Tsai CF, Yeh WL, Chen JH, Lin C, Huang SS, Lu DY. (2014, Mar). Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression. Int J Mol Sci. 15(3):3889-903 .

 

16. Chen YS; Chen SD; Wu CL; Huang SS; Yang DI. (2014, Mar). Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture. Experimental Neurology, 253:63-71.

 

17. Huang SS, Lu YJ, Huang JP, Wu YT, Day YJ, Hung LM. (2014, Feb). The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. Journal of vascular surgery. 59(2):483-91. NSC 100-2320-B-040-007.

 

18 Lin HY, Huang BR, Yeh WL, Lee CH, Huang SS, Lai CH, Lin H, Lu DY. (2014, Jan). Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways. NEUROBIOLOGY OF AGING, 35:191-20.

 

19. Tsai MJ, Tsai SK, Hu BR, Liou DY, Huang SL, Huang MC, Huang WC, Cheng H, Huang SS*. (2014, Jan). Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats. Journal of Biomedical Science, 21:5. NSC 100-2320-B-040-007.

 

20. Lin YK, Chen YC, Huang JH, Lin YJ, Huang SS, Chen SA, Chen YJ. (2013, Dec). Leptin modulates electrophysiological characteristics and isoproterenol-induced arrhythmogenesis in atrial myocytes. Journal of Biomedical Science. 20:94.

 

21. Lu DY, Huang BR, Yeh WL, Lin HY, Huang SS, Liu YS, Kuo YH. (2013, Dec). Anti-neuroinflammatory effect of a novel caffeamide derivative, KS370G, in microglial cells. MOLECULAR NEUROBIOLOGY, 48:863-74.

 

22. Huang SS, Cheng H, Tang CM, Nien MW, Huang YS, Lee IH, Yin JH, Kuo TB, Yang CC, Tsai SK, Yang DI. (2013, Sep). Anti-oxidative, anti-apoptotic, and proangiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. EXPERIMENTAL NEUROLOGY, 247:680-88. NSC 100-2320-B-040 -007.

 

23. Huang BR, Tsai CF, Lin HY, Tseng WP, Huang SS, Wu CR, Lin C, Yeh WL, Lu DY. (2013, May). Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid. TOXICOLOGY AND APPLIED PHARMACOLOGY, 269(1):43-50.

 

24. Huang SS, Su HH, Kuo TB, Chen CY, Lan YY, Liu BY, Yang DI, Tsai SC, Yang CC (2012, Aug). Suppressing cardiac vagal modulation and changing sleep patterns in rats after chronic ischemic stroke injury. Auton Neurosci, 169(2):116-23. NSC 100-2320-B-040-007.

 

25. Ho YJ, Chen FL, Liu SM, Wang AL, Li YC, Lai TJ, and Huang SS* (2012, Aug). Effects of Chronic Resistive Airway Loading on Behavioral Changes in Rats. Chin J Physiol., 55(4):245-52.

 

研討會論文

 

1. Hsing-Hui Su, Yi-Hsin Wang, Jiuan-Miaw Liao, Jiin-Cherng Yen, Shiang-Suo Huang* (2017, May). Neuroprotective effect of GDF11 protects against ischemic stroke. 26th European Stroke Conference, Berlin, Germany.

 

2. 姚懿庭, 廖娟妙, 黃相碩, (2017, Mar). The Role of Autophagy on the Cardioprotective Effect of Paeonol. 2017 The 32th Joint Annual Conference of Biomedical Science, National Defense Medical Center, Taipei, Taiwan.

 

3. Lin S.M., Tsai S.K., Chih C. L., Nien M.W., Huang S.S (2012, Apr). Wogonin reduces infarct size and improves ventricular function in chronic myocardial ischemia rats. Experimental Biology 2012 , Harbor Drive, San Diego, California, USA..