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宋文瑋 助理教授

Wen-Wei Sung, M.D., Ph.D.


實驗室 研究大樓七樓

電話 (04) 2473-9595 ext.34803

傳真 (04) 24728098



現任:中山醫學大學醫學系 助理教授 (2017.08 ~)

           中山醫學大學附設醫院泌尿科 住院醫師 (2017.08 ~)


學歷:中山醫學大學醫學系(醫學士-博士學程) 醫學士-博士 (2016.06)


研究興趣: 腫瘤免疫學、癌症生物學、轉譯醫學、泌尿生殖生理學




導生時間(office hour) (每月因臨床工作調整)




  1. 2017.08~: Principal Investigator: School of Medicine, Chung Shan Medical University
  2. 2014~2017: Cooperative Researcher: Institute of Medicine, Chung Shan Medical University (Prof. Jiunn-Liang Ko); Department of Surgical Pathology, Changhua Christian Hospital (Prof. Kun-Tu Yeh; Dr. Chih-Jung Chen)
  3. 2004~2012: M.D.-Ph.D. Student: Division of Environmental Health and Occupational Medicine, National Health Research Institutes; Institute of Medical & Molecular Toxicology and Institute of Medicine, Chung Shan Medical University (Laboratory of Genetic Toxicology, Prof. Huei Lee)
  4. 2007: Exchange Student: Department of Pathology, University of Turku, Finland (Prof. Yrjo Collan)
  5. 2001~2003: High School Student: Department of Entomology, National Chung Hsing University (Laboratory of Theoretical Ecology/ Prof. Hsin Chi); Academia Sinica (Biodiversity Research Center/ Dr. Shun-Chern Tsaur)



  1.  World Journal of Gastrointestinal Oncology



  1. International Journal of Cancer
  2. Cancer
  3. Cancers
  4. Aging
  5. World Journal of Gastroenterology
  6. World Journal of Gastrointestinal Oncology
  7. Tumor Biology
  9. BMJ Open
  10. Journal of Clinical Pathology
  11. Medicine
  12. World Journal of Surgical Oncology
  13. International Journal of Environmental Research and Public Health
  14. Brain Sciences
  15. Medical Science Monitor
  16. Journal of Oral Pathology and Medicine
  17. Oncotarget
  18. Journal of Clinical Laboratory Analysis
  19. World Journal of Clinical Oncology
  20. Asia-Pacific Journal of Clinical Oncology
  21. World Journal of Clinical Cases
  22. Journal of Clinical Trials
  23. Biomedical Research
  24. Advanced Materials Science Research
  25. Journal of Medical & Surgical Pathology
  26. Journal of Gastroenterology and Its Complications
  27. Cancer Science & Research: Open Access
  28. Acta Medica Philippina
  29. JSM Surgical Oncology and Research
  30. EBioMedicine
  31. Journal of Clinical & Experimental Cardiology
  32. Hepatology and Pancreatic Science
  33. Dentistry Journal






200920102011:教育部獎助醫師科學家 (博士班)



  1. Co-Principal Investigator: Role of WISP1/2 and related genes in promoting tumor malignancy of liver and colorectal cancer. Chung Shan Medical University Hospital (2020/01/01~2020/12/31)
  2. Co-Principal Investigator: Cardio-respiratory training improves immune surveillance through modification of lung microenvironments: evidence in primary tumor model of renal cancer. Chung Shan Medical University Hospital (2020/01/01~2020/12/31)
  3. Principal Investigator: Chidamide overcomes drug resistance to mitomycin C via attenuating DNA repair ability in intravesical instillation model for urothelial carcinoma: from molecular mechanism to clinical evidence. Ministry of Science and Technology (108-2314-B-040-014-MY3, 2019/08/01~2022/07/31)
  4. Co-Principal Investigator: Coenzyme Q contributes to bladder remodeling via modulation of microenvironment in interstitial cystitis model. Ministry of Science and Technology (108-2314-B-040-015-, 2019/08/01~2020/07/31)
  5. Co-Principal Investigator: Evaluation the therapeutic role of platelet-rich plasma in interstitial cystitis. Ministry of Science and Technology (107-2314-B-040-008-, 2018/08/01~2019/07/31)
  6. Principal Investigator: The therapeutic role of Azacitidine in chemoresistant bladder cancer. Chung Shan Medical University Hospital (2018/01/01~2018/12/31)
  7. Principal Investigator: Evaluation the therapeutic role of histone deacetylase inhibitors in chemoresistant bladder cancer via intravesical instillation. Ministry of Science and Technology (106-2314-B-040-026-MY2, 2017/10/01~2019/09/30)
  8. Principal Investigator: Evaluation of the prognostic role and its molecular mechanism of KLF17 in oral cancer. Chung Shan Medical University Hospital (2017/01/01~2017/12/31)










演講邀請、研討會論文與國際會議 (2017-)


  1. Oral presentation, ISP02-01. The 108th Annual Meeting of the Japanese Urological Association (JUA), Kobe, Japan.
  2. Expert-guided poster tours, PT363. 35th Annual EAU Congress Amsterdam (EAU20), Amsterdam, Netherlands.
  3. Expert-guided poster tours, PT146. 35th Annual EAU Congress Amsterdam (EAU20), Amsterdam, Netherlands.


  1. Invitation to Young Urologist Review Course. Korean Urological Association (KUA) Annual Meeting, Seoul, Korea.
  2. Poster, MP037. Taiwan Urology Association 2019 Annual Meeting, Taichung, Taiwan.
  3. Poster, 2P-468. The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan.


  1. Poster, UP-332. 38th Congress of the Société Internationale d'Urologie (SIU), Seoul, Korea.
  2. Poster, UP-023. The 16th Urological Association of Asia (UAA) Congress 2018, Kyoto, Japan. 
  3. Poster, UP-048. The 16th Urological Association of Asia (UAA) Congress 2018, Kyoto, Japan.
  4. Invited speech. The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. Immune Checkpoint Inhibitors in Urogenital Cancers.


  1. Poster, NDP018. Taiwan Urology Association 2017 Annual Meeting, Kaohsiung, Taiwan.
  2. Poster, NDP078. Taiwan Urology Association 2017 Annual Meeting, Kaohsiung, Taiwan.




  1. Wang CC, Yang TW, Sung WW, Tsai MC. Current Endoscopic Management of Malignant Biliary Stricture. Medicina (Kaunas). 2020 Mar 5;56(3). pii: E114.
  2. Lee YJ, Chan L, Yeh CM, Lee CH*, Sung WW*. Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. Medicina (Kaunas). 2020 Jan 30;56(2). pii: E57.


  1. Chen WJ, Huang CY, Huang YH, Wang SC, Hsieh TY, Chen SL, Sung WW*, Lee TH*. Correlations between Mortality-to-Incidence Ratios and Health Care Disparities in Testicular Cancer. Int J Environ Res Public Health. 2019 Dec 23;17(1). pii: E130. (*equal contribution)
  2. Yang TH, Chang CS, Sung WW, Liu JT. Lumboperitoneal Shunt: A New Modified Surgical Technique and a Comparison of the Complications with Ventriculoperitoneal Shunt in a Single Center. Medicina (Kaunas). 2019 Sep 26;55(10). pii: E643.
  3. Lee TH*, Sung WW*, Chan L, Lee HL, Chen SL, Huang YH, Kwan AL. The Association between Mortality-to-Incidence Ratios and Health Expenditures in Brain and Nervous System Cancers. Int J Environ Res Public Health. 2019 Jul 31;16(15). pii: E2739. (*equal contribution)
  4. Wang CC, Tsai MC, Wang SC, Peng CM, Lee HL, Chen HY, Yang TW, Lin CC*, Sung WW*. Favorable Gallbladder Cancer Mortality-To-Incidence Ratios of Countries with Good Ranking of World’s Health System and High Expenditures on Health. BMC Public Health. 2019 Jul 31;19(1):1025. (*corresponding author)
  5. Chen ML, Ho CJ, Yeh CM, Sung WW, Chen SL, Wang SC, Chen CJ. High SPOCK1 expression is associated with advanced stage, T value, and Gleason grade in prostate cancer. Medicina. 2019 Jul 5;55(7). pii: E343.
  6. Lee TH, Huang YH, Su TM, Chen CF, Lu CH, Lee HL, Tsai HP, Sung WW*, Kwan AL*. Predictive Factors of 2-Year Postoperative Outcomes in Patients with Spontaneous Cerebellar Hemorrhage. J Clin Med. 2019 Jun 8;8(6). pii: E818. (*corresponding author)
  7. Wang CC, Tsai MC, Sung WW, Yang TW, Chen HY, Wang YT, Su CC, Tseng MH, Lin CC. Risk of cholangiocarcinoma in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography or cholecystectomy: A population based study. World J Gastrointest Oncol. Mar 15, 2019; 11(3): 238-249.
  8. Wang CC, Tsai MC, Wang YT, Yang TW, Chen HY, Sung WW, Huang SM, Tseng MH, Lin CC. Role of Cholecystectomy in Choledocholithiasis Patients Underwent Endoscopic Retrograde Cholangiopancreatography. Sci Rep. 2019 Feb 18;9(1):2168.


  1. Huang CY, Au KK, Chen SL, Wang SC, Liao CY, Hsu HH, Sung WW*, Wang YC*. Unfavorable Mortality-To-Incidence Ratio of Lung Cancer is Associated with Health Care Disparity. Int J Environ Res Public Health. 2018 Dec 13;15(12). pii: E2889. (*corresponding author)
  2. Su TC, Chen CY, Tsai WC, Hsu HT, Yen HH, Sung WW*, Chen CJ*. Cytoplasmic, Nuclear, and Total PBK/TOPK Expression is Associated with Prognosis in Colorectal Cancer Patients: a Retrospective Analysis Based on Immunohistochemistry Stain of Tissue Microarrays. PLoS One. 2018 Oct 4;13(10):e0204866. (*corresponding author)
  3. Tsai MC, Yang TW, Wang CC, Wang YT, Sung WW, Tseng MH, Lin CC. Favorable clinical outcome of nonalcoholic liver cirrhosis patients with coronary artery disease: A population-based study. World J Gastroenterol. 2018 Aug 21;24(31):3547-3555.
  4. Sung WW, Wang SC, Hsieh TY, Ho CJ, Huang CY, Kao YL, Chen WJ, Chen SL. Favorable mortality-to-incidence ratios of kidney cancer are associated with advanced health care systems. BMC Cancer. 2018 Aug 6;18(1):792.
  5. Lee HL, Peng CM, Huang CY, Wu SY, Tsai MC, Wang CC, Chen SL, Lin CC, Huang CN, Sung WW*. Is mortality-to-incidence ratio associated with health disparity in pancreatic cancer? A cross-sectional database analysis of 57 countries. BMJ Open. 2018 Jul 6;8(7):e020618. (*corresponding author)
  6. Chang CC, Sung WW, Hsu HT, Yeh CM, Lee CH, Chen YL, Liu YC, Yeh KT. Validation of EGFL6 expression as a prognostic marker in lung adenocarcinoma patients in Taiwan: a retrospective study. BMJ Open. 2018 Jun 22;8(6):e021385.


  1. Tsai MC, Wang CC, Lee HL, Peng CM, Yang TW, Chen HY, Sung WW*, Lin CC*. Health Disparities Are Associated with Gastric Cancer Mortality-To-Incidence Ratios in 57 Countries. World J Gastroenterol. 2017 Nov 28;23(44):7881-7887. (*corresponding author)
  2. Wang CC, Tsai MC, Peng CM, Lee HL, Chen HY, Yang TW, Sung WW*, Lin CC*. Favorable Liver Cancer Mortality-To-Incidence Ratios of Countries with High Health Expenditure. Eur J Gastroenterol Hepatol. 2017 Dec;29(12):1397-1401. (*corresponding author)
  3. Wang SC*, Sung WW*, Kao YL, Hsieh TY, Chen WJ, Chen SL, Chang HR. The gender difference and mortality-to-incidence ratio relate to health care disparities in bladder cancer: National estimates from 33 countries. Sci Rep. 2017 Jun 28;7(1):4360. (*equal contribution)
  4. Hsu LS, Huang RH, Lai HW, Hsu HT, Sung WW, Hsieh MJ, Wu CY, Lin YM, Chen MK, Lo YS, Chen CJ. KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities. Int J Med Sci. 2017 Apr 9;14(6):530-535.
  5. Chen CJ, Sung WW, Chen HC, Chern YJ, Hsu HT, Lin YM, Lin SH, Peck K*, Yeh KT*. Early Assessment of Colorectal Cancer by Quantifying Circulating Tumor Cells in Peripheral Blood. Int J Mol Sci. 2017 Mar 31;18(4). pii: E743.
  6. Su HA, Sun PL, Sung WW, Cheng SY, Chang HC, Yang JH, Hsiao YP. Deep Dermatophytosis Caused by Zoophilic Strain of Trichophyton interdigitale with Successful Treatment of Itraconazole. Mycopathologia. 2017 Aug;182(7-8):715-720.
  7. Chen SL, Wang SC, Ho CJ, Kao YL, Hsieh TY, Chen WJ, Chen CJ, Wu PR, Ko JL, Lee H, Sung WW*. Prostate Cancer Mortality-To-Incidence Ratios Are Associated with Cancer Care Disparities in 35 Countries. Sci Rep. 2017 Jan 4;7:40003. (*corresponding author)


  1. Chang CF, Chen SL, Sung WW, Hsieh MJ, Hsu HT, Chen LH, Chen MK, Ko JL, Chen CJ, Chou MC. PBK/TOPK Expression Predicts Prognosis in Oral Cancer. Int J Mol Sci. 2016 Jun 24;17(7). pii: E1007.
  2. Chiu LY, Hsin IL, Yang TY, Sung WW, Chi JY, Chang JT, Ko JL, Sheu GT. The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Oncogene. 2016 Jun 6; 36(2):242-253.
  3. Lee CH, Chen SL, Sung WW, Lai HW, Hsieh MJ, Yen HH, Su TC, Chiou YH, Chen CY, Lin CY, Chen ML*, Chen CJ*. The Prognostic Role of STEAP1 Expression Determined via Immunohistochemistry Staining in Predicting Prognosis of Primary Colorectal Cancer: A Survival Analysis. Int J Mol Sci. 2016 Apr 19;17(4). pii: E592.
  4. Yeh CM*, Sung WW*, Lai HW, Hsieh MJ, Yen HH, Su TC, Chang WH, Chen CY, Ko JL, Chen CJ. Opposing Prognostic Roles of Nuclear and Cytoplasmic RACGAP1 Expression in Colorectal Cancer Patients. Hum Pathol. 2016 Jan;47(1):45-51. (*equal contribution)


  1. Lin YM*, Sung WW*, Hsieh MJ, Tsai SC, Lai HW, Yang SM, Shen KH, Chen MK, Lee H, Yeh KT, Chen CJ. High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. PLoS One. 2015 Nov 12;10(11):e0142656. (*equal contribution)
  2. Hwang JC, Sung WW, Tu HP, Hsieh KC, Yeh CM, Chen CJ, Tai HC, Hsu CT, Shieh GS, Chang JG, Yeh KT, Liu TC. The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma. PLoS One. 2015 Oct 2;10(10):e0139435.


  1. Sung WW, Lin YM, Wu PR, Yen HH, Lai HW, Su TC, Huang RH, Wen CK, Chen CY, Chen CJ, Yeh KT. High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients. BMC Cancer. 2014 Dec 15;14:951. 
  2. Wu DW, Chuang CY, Lin WL, Sung WW, Cheng YW, Lee H. Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting. Carcinogenesis. 2014 Aug;35(8):1823-9.


  1. Sung WW and Lee H. The Role of Interleukin-10 in Tumor Progression of Human Papillomavirus-Associated Non-Small Cell Lung Cancer. OncoImmunology. 2013 Sep 1;2(9):e25854.
  2. Sung WW, Wang YC, Lin PL, Cheng YW, Chen CY, Wu TC, Lee H. IL-10 Promotes Tumor Aggressiveness via Upregulation of CIP2A Transcription in Lung Adenocarcinoma. Clin Cancer Res. 2013 Aug 1;19(15):4092-103. (CCR Highlights)
  3. Wang YC*, Sung WW*, Wang L, Cheng YW, Chen CY, Wu TC, Shieh SH, Lee H. Different Impact of IL10 Haplotype on Prognosis in Lung Squamous Cell Carcinoma and Adenocarcinoma. Anticancer Res. 2013 Jun;33(6):2729-35. (*equal contribution)
  4. Tang SC, Wu CH, Lai CH, Sung WW, Yang WJ, Tang LC, Hsu CP, Ko JL. Glutathione s-transferase mu2 suppresses cancer cell metastasis in non-small cell lung cancer. Mol Cancer Res. 2013 May;11(5):518-29.
  5. Chen CJ, Sung WW, Su TC, Chen MK, Wu PR, Yeh KT, Ko JL, Lee H. High expression of interleukin 10 might predict poor prognosis in early stage oral squamous cell carcinoma patients. Clin Chim Acta. 2013 Jan 16;415:25-30.


  1. Chen CJ, Sung WW, Lin YM, Chen MK, Lee CH, Lee H, Yeh KT, Ko JL. Gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma. PLoS One. 2012;7(11):e50104. 
  2. Chuang CY*, Sung WW*, Wang L, Lin WL, Yeh KT, Su MC, Hsin CH, Lee SY, Wu BC, Cheng YW, Lee H. Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas. PLoS One. 2012;7(10):e47541. (*equal contribution)
  3. Chen TH, Huang CC, Yeh KT, Chang SH, Chang SW, Sung WW, Cheng YW, Lee H. Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. World J Gastroenterol. 2012 Aug 14;18(30):4051-8.
  4. Wang YC*, Sung WW*, Wu TC, Wang L, Chien WP, Cheng YW, Chen CY, Shieh SH, Lee H. Interleukin-10 haplotype may predict survival and relapse in resected non-small cell lung cancer. PLoS One. 2012;7(7):e39525. (*equal contribution)
  5. Tsai LL, Yu CC, Lo JF, Sung WW, Lee H, Chen SL, Chou MY. Enhanced cisplatin resistance in oral-cancer stem-like cells is correlated with upregulation of excision-repair cross-complementation group 1. J Dent Sci. 2012 Jun; 7(2):111–7.


  1. Sung WW, Wang YC, Cheng YW, Lee MC, Yeh KT, Wang J, Chen CY, Lee H. A polymorphic -844T/C in fasl promoter predicts survival and relapse in non-small cell lung cancer. Clin Cancer Res. 2011 Sep 15;17(18):5991-9. (CCR Highlights)


更新日期: 2020/03/18