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分類清單
李秀雄 講座教授

李秀雄

Lee Hsiu-Hsiung

學歷: 國立日本濱松醫科大學

專長:

1. 寄生蟲學   

2. 牙醫學

3. 藥理學

 

研究領域

1.   寄生蟲分子生物學之探討

2.   寄生蟲藥物治療之分子機轉

 

 李秀雄教授

研究計畫            

 

1.   評估albendazole及安宮牛黃丸混合治療廣東住血線蟲感染BALB/c小白鼠所引發嗜伊紅性腦膜炎之效果  2005/08/01~2006/07/31

2.   評估板藍根及albendazole混合治療廣東住血線蟲感染BALB/c小白鼠所引發腦膜炎之效果  2004/08/01~2005/07/31

3.   驅蟲藥 albendazole 和薑黃素合併治療感染廣東住血線蟲小鼠之療效  2003/08/01~2004/07/31

4.   分析廣東住血線蟲再不同發育時其所製造的蛋白分解酵素  2001/08/01~2002/07/31

5.   GM6001( Ilomastat)治療廣東住血線蟲感染所引發腦膜炎的效果研究  2001/08/01~2002/07/31

 

近五年論文發表

A Referred paper

  1. Lee, H. H. Shiow,S. J., Chung, H. C., Huang, C. Y., Lin, C. L., Hsu, J. D., Shyu, Y. L., and Wang, C. J. 2000.  Development of brain injury in mice by Angiostrongylus cantonensis infection is associated with the induction of transcripition factor NF-kB, nuclear protooncogenes, and protein tyrosine phosphorylation. Experimental parasitology, 95: 202-208. (SCI)
  2. Lai, S. C., Chen, K. M., Yang, J. P., Liu, J. P., Hsu, C. C., Lee, Y. H., Jen, S. Y., Huang, J. W., and Lee, H. H. 2003. Upregulation of MMP-9 in mouse cerebellum with Purkinje cell loss caused by Angiostrongylus cantonensis. The Chung-Shan Medical Journal 14: 485-493
  3. Lan, K. P., Wang, C. J., Lai, S. C. Chen, K. M., Lee, S. S., Hsu, J. D., and Lee, H. H. 2004. The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitology Research 93: 311-317. (SCI)
  4. Chen, K. M., Lee, H. H., Lu, K. H., Tseng, Y. K., Hsu, L. S., Chou, H. L., and Lai, S. C. 2004. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. International Journal for Parasitology 34: 1147-1156. (SCI)
  5. Lai, S. C., Twu, J. J., Jiang, S. T., Hsu, J. D., Chen, K. M., Chiaing, H. C., Wang, C. J., and Lee, H. H. 2004. Induction of matrix-metalloproteinase-9 in the pathogenesis of eosinophilic meningitis caused by Angiostrongylus cantonensis. Annal Tropical and Medicine and Parasitology 98: 715-724. (SCI)
  6. Lee, H. H., Chou, H. L., Chen, K. M., Lai, S. C. 2004. Association of matrix-metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitology Research 94: 321-328. (SCI)
  7. Hou, R. F., Tu, W. C., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2004. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. International Journal for Parasitology 34: 1355-1364. (SCI)
  8. Lan, K. P., Wang, C. J., Hsu, J. D., Chen, K. M., Lai, S. C. and Lee, H. H. 2004. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mice brain is associated with the induction of JAK/STAT1, IAP/NF-κB and MEKK1/JNK signals. Journal of Helminthology 78: 311-317. (SCI)
  9. Tseng, Y. K., Tu, W. C., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2004. Ultrastructural localization of matrix metalloproteinase-9 in CSF eosinophils of mice with eosinophilic meningitis. Annal Tropical and Medicine and Parasitology. 98: 831-841. (SCI)
  10. Chen, K. M., Lee, H. H., Tsai, B. C., Kung, C. C., and Lai, S. C. 2004. Association of matrix metalloproteinases with blood-brain barrier damage of angiostrongyliasis. The Chung-Shan Medical Journal 15: 195-204.
  11.  Hsu, L. S., Lee, H. H., Chen, K. M., Chou, H. L. and Lai, S. C. 2005. Matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. Annal Tropical and Medicine and Parasitology 99: 61-70. (SCI)
  12. Lai, S. C., Jiang, S. T., Chen, K. M., Hsu, J. D., Shyu, L. Y., and Lee, H. H. 2005. Efficacy of albendazole–GM6001 co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. Acta Tropica 93: 267-173. (NSC-90-2320-B-040-015) (SCI)
  13. Lai, S. C., Chen, K. M., Chen, H. C. Lee, H. H. 2005. Induction of matrix metalloproteinase- 9 in mice during Toxocara canis larvae migration. Parasitology Research 95: 193-200. (SCI)
  14. Chen, K. M., Lee, H. H., Chou, H. L., Liu, J. Y., Tsai, B. C., Lai, S. C. 2005. Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. International Journal of Experimental Pathology 86: 81-89. (SCI)
  15. Lai, S. C., Jiang, S. T., Chen, K. M., Lee, H. H. 2005. Matrix metalloproteinases activity demonstrated in the infective stage of the nematodes, Angiostrongylus cantonensis. Parasitology research. 97:466-471. (SCI)

B Conference paper

 

  1. Lai, S. C., Jiang, S. T., Shyu, L. Y., Chen, K. M., and Lee, H. H. 2002. The efficacy of combining therapy with albendazole and GM6001 in parasitic meningitis caused by Angiostrongylus cantonensis-infected mice. The Seventeenth Joint Annual Conference of Parasitology, Tainan. P. 20.
  2.  Lai, S. C., Shyu, L. Y., Chen, K. M., Lee, H. H. 2003. MMP-9 and its inhibitor in mice with parasitic meningitis caused by Angiostrongylus cantonensis.The First Meeting of the China and Taiwan Parasitology, Taipei. P.131.
  3. Yang, J. P., Lee, H. H., Chen, K. M., Liu, J. P., Hsu, C. C., Lee, Y. H., Jen, S. Y., Huang, J. W., and Lai. S. C. 2003. The role of MMP-9 in mice cerebellum with Purkinje cell degeneration caused by Angiostrongylus cantonensis. The Eighteenth Joint Annual Conference of Parasitology, Taipei. P. 34.
  4.  Lan, K. P., Wang, C. J., Hsu, J. D., Chen, K. M., Lai, S. C., Lee, H. H. 2003. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mice brain is associated with the induction of JAK/STAT1, IAP/NFκB and MEKK1/JNK signals. The Eighteenth Joint Annual Conference of Parasitology, Taipei. P. 33.
  5. Liu, J. P., Chen, K. M., Lee, H. H., Huang, J. W., Lai, S. C. 2004. Efficacy of albendazole-dexamethasone co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Eighth Asian-Pacific Congress for Parasitic Zoonoses (8th APCPZ), Taiwan. P. 41.
  6. Tsai, B. C., Chen, K. M., Lee, H. H., Wu, C. H., Lai, S. C. 2004. Induction of plasminogen activators in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. The Eighth Asian-Pacific Congress for Parasitic Zoonoses (8th APCPZ), Taiwan. P. 42.
  7. Cheng, W. C., Lai, S. C., Lee, H. H. 2004. The study of maggot therapy in problem wounds. Symposium of the University Faculty’s Research Projects on Special Topics. Chung Shan Medical University Commemoration of the 44th Anniversary. Taiwan. P. 19.
  8. Liu, J. P., Lee, H. H., Chen, K. M., Kuan, I. T., Lai, S. C. 2004. Efficacy of albendazole-dexamethasone co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 25.
  9. Tsai, B. C., Lee, H. H., Chen, K. M., Wu, C. H., Lai, S. C. 2004. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis  The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 26.
  10. Chang,Y. H., Lai, S. C., Chen, K. M., Hsu, Y. L., Lee, H. H. 2004. Efficacy of albendazole and Long-dan-xie-gan-tan co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 40.
  11. Jen, S. Y., Lee, H. H., Chen, K. M., Lee, Y. H., Lai, S. C. 2004. Matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 41.
  12. Huang, J. W., Lee, H. H., Chen, K. M., Hsu, C. C., Lai, S. C. 2004 Ultrastructural localization of matrix metalloproteinase-9 in CSF eosinophils of mice with eosinophilic meningitis. The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 42.
  13. Chen, K. C. Lee, H. H., Chen, K. M., Chang, S. F., Lee, C. Y., Lai, S. C. 2004. Association of matrix metalloproteinases with blood-brain barrier damage of angiostrongyliasis. The Nineteenth Joint Annual Conference of Parasitology, Taichung. P. 43.
  14. Chen, K. M., Kuan, I. T., Lai, S. C. 2005. The roles of matrix metalloproteinase-2, and -9 in granulomatous fibrosis of rat infected with Angiostrongylus cantonensis. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei. P. 333.
  15.  Chen, K. M., Wu, C. H., Lai, S. C. 2005. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. The Twentieth Joint Annual Conference of Biomedical Sciences, Taipei. P. 362.