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分類清單
郭東益老師

 

郭東益 教授
Dong-Yih Kuo, Ph.D

學經歷及專長介紹                                           
1. 學歷:成功大學基礎醫學研究所博士。
2. 經歷:●中山醫大醫學系講師、副教授、教授。
●中山醫大課務組主任,生理科科主任。
●考選部國家考試命題(生理學)委員。
● 98-99 年度國科會專題研究計畫審查委員。
●獲國科會99年度補助大專校院獎勵特殊優秀人才。
●獲國科會第36屆補助科技人員研究及進修(36299D)。
●獲選美國名人學術機構(The American Biographical Institute)之「2011 Man of the Year in Medicine &  Healthcare」。
●獲選英國名人中心(International Biographical Center)之「Top 100 Health Profession 2012」。
●榮獲刊登Who’s Who 亞太名人錄 (2005-2011)。
●私立醫學院聯合招考轉學生委員會委員。
●中山醫學大學醫學系甄試入學委員。
●中山醫學大學醫學系課程委員會委員。
●中山醫學大學醫學院教師成長中心執行委員
●中山醫學大學醫學系醫學教育卓越團隊委員
●國際學術期刊審查委員:
(1)Journal of Neurochemistry 審查委員,
(2) Journal of Pharmacology and Experimental Therapy 審查委員,
(3) Toxicology Research 審查委員,
(4) Behavioral Neuroscience審查委員。
● 98-100年度高雄醫大、中國醫大、中山醫大、台中護專等校專題研究計畫審查委員。
3. 現任:生理科科主任、醫學系生理科教授
4. 專長:生理學、神經訊息傳遞、神經內分泌、神經藥理、神經毒理、腦科學。


專題研究計劃                                        

  • 國科會

計畫名稱

補助或委託機構

起訖年月

計畫內擔任的工作

下視丘POMC神經路徑在厭食劑引發之毒性及行為反應之機制(NSC 98-2320-B-040-009-MY3)

行政院國家科學委員會

2009/8/1 至 2012/7/31

主持人

CART神經傳遞路徑在安非他命它命的毒性及厭食作用所扮演之角色(NSC 96-2320-B-040-018-MY2)

行政院國家科學委員會

2007/8/1 至 2009/7/31

主持人

腦內MAPK訊息傳遞路徑在「安非它命的厭食作用」及「NPY基因表現」之角色(NSC95-2320-B-040-008-)

行政院國家科學委員會

2006/8/1 至 2007/7/31

主持人

腦內PKA-CREB訊息傳遞路徑在安非它命重複刺激引發之厭食效應之角色(NSC 94-2320-B-040-018-)

行政院國家科學委員會

2005/8/1 至 2006/7/31

主持人

下視丘旁室核微量注射蛋白激藥物對「安非他命引發之厭食作用」在自由活動動物的效應(NSC 93-2320-B-040-016- )

行政院國家科學委員會

2004/8/1 至 2005/7/31

主持人

尼古丁在耐受性大白鼠對中腦邊緣多巴安系統之生化及電生理上的作用。第36屆(87年度)科技人員研究及進修(NSC 36299D)

行政院國家科學委員會

2000/8/1 至 2002/7/31

主持人

  • 其它機構補助申請

 

計畫名稱

補助或委託機構

起訖年月

計畫內擔任的工作

下視丘POMC神經路徑在厭食劑引發之毒性及行為反應之機制 (B098N0246-MY3)

中山醫學大學

2009/08/01 至 2012/07/31

主持人

CART神經傳遞路徑在安非他命它命的毒性及厭食作用所扮演之角色(CSMU 96-OM-A-064)

中山醫學大學

2007/08/01 至 2008/07/31

主持人

腦內Cocaine and Amphetamine-Related Transcript (CART)神經傳導系統在Amphetamine誘發之毒性及厭食效應之角色探討。(DOH 95-NNB-1018)

衛生署計劃

2006/01/01 至 2006/12/31

共同主持人

The role of hypothalamic neuropeptide y in the control of anorectic agent-induced food intake inhibition. (CSMU 93-OM-B-023)

中山醫學大學

2005/10/01 至 2006/07/31

主持人

Immunohistochemical method to study the molecular mechanism of amphetamine-induced anorexia. (CSMU 92-OM-B-023)

中山醫學大學

2004/10/01 至 2005/07/31

主持人

下室丘Y型神經胜肽(NPY)在安非它命厭食作用之分子機制(CSMC 89-OM-B-021)

中山醫學大學

2000/08/01 至 2001/07/30

主持人

Possible mechanism of neuropeptide Y and dopamine interact centrally in the control of food intake. (CSMC 88-OM-B-030)

中山醫學大學

1999/08/01 至 2000/07/30

主持人

Is the effect of nicotine on motor activity modified by the estrous cycle, ovariectomy, and estradiol replacement in rats? (CSMC 85-OM-B-015)

中山醫學大學

1996/08/01 至 1997/07/30

主持人

Effects of nicotine on amphetamine-induced behavioral response of acute nicotine-tolerant rats.( CSMC 83-NS-B-024)

中山醫學大學

1994/08/01 至 1995/07/30

主持人

The effect of nicotine exposure on drug-induced Parkinsonian rats.( CSMC 81-1-023)

中山醫學大學

1992/08/01 至 1993/07/30

主持人

著作目錄                                            

  • 研討會論文

著作種類

題目

發表年月
(出版年月)

研討會名稱

研討會論文

Knocking Down the Transcript of NF-kappaBn Modulates the Reciprocal Regulation of Endogenous Antioxidants and Feeding Behavior in Phenylpropanolamine-Treated Rats

2012/03

第25屆生物醫學聯合學術年會

研討會論文

Participation of NF-kappaB in neuropeptide Y and proopiomelanocortin gene expressions and in the regulation of amphetamine-mediated behavioral response

2011/04

第三届澳洲-中国生物医学研究大会

研討會論文

The effect of protein kinase C-delta knockdown on anti-free radical enzyme and neuropeptide Y gene expression in phenylpropanolamine-treated rats

2010/06

1st Annual World Congress of NeuroTalk (NeuroTalk-2010)-Singapore

研討會論文

Amphetamine-evoked changes of oxidative stress and neuropeptide Y gene expression in hypothalamus: regulation by the protein kinase C-delta signaling

2010/03

第25屆生物醫學聯合學術年會

研討會論文

ACTIVATION OF C-FOS/C-JUN SIGNALING ARE INVOLVED IN NEUROPEPTIDE Y GENE EXPRESSION IN AMPHETAMINE-MEDIATED APPETITE SUPPRESSION

2009/07

XXXVIth International Congress of Physiological Sciences (IUPS2009) Japan

研討會論文

Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression.

2009/03

第24屆生物醫學聯合學術年會

研討會論文

Interrupting Activator Protein-1 Signaling in Conscious Rats Can Modify Neuropeptide Y Gene.

2009/03

第24屆生物醫學聯合學術年會

研討會論文

Intracerebral administration of protein kinase A (PKA) or c-AMP response element binding protein (CREB) antisense oligonucleotide can modulate amphetamine-mediated appetite suppression in freely-moving rats

2006/03

第二十一屆生物醫學聯合學術年會報告

研討會論文

Immunohistochemical and genomic evidence for the involvement of hypothalamic neuropeptide Y in phenylpropranolamine-mediated appetite suppression

2003/11

九十二年中山醫學院教師專題研究計劃發表會(第十一屆)

研討會論文

The role of hypothalamic neuropeptide y in the control of anorectic agent-induced food intake inhibition.

2000/11

八十九年中山醫學院教師專題研究計劃發表會(第八屆)

研討會論文

Possible mechanism of neuropeptide Y and dopamine interact centrally in the control of food intake.

1999/11

八十八年中山醫學院教師專題研究計劃發表會(第七屆)

研討會論文

Is the effect of nicotine on motor activity modified by the estrous cycle, ovariectomy, and estradiol replacement in rats?

1996/11

八十五年中山醫學院教師專題研究計劃發表會(第四屆)

研討會論文

Effects of nicotine on amphetamine-induced behavioral response of acute nicotine-tolerant rats.

1994/11

八十三年中山醫學院教師專題研究計劃發表會(第二屆)

研討會論文

The effect of nicotine exposure on drug-induced Parkinsonian rats

1992/11

八十一年中山醫學院教師專題研究計劃發表會(第一屆)

2.期刊論文(僅列SCI論文)

論文標題

發表年月(出版年月)

期刊名稱

Kuo DY, Chen PN, Kuo MH, Chen CH, Hsieh YS, Chu SC*. NF-kappaB knockdown can modulate amphetamine-mediated feeding response. 2011, PMID: 22182781, doi: 10.1016/j.neuropharm.2011.11.014.

2012/02

Neuropharmacology. (IF:4.677, Rank:9.92 %)

Kuo DY, Chen PN, Chu SC, Hsieh YS. (2011). Knocking down the Transcript of NF-kappaBn Modulates the Reciprocal Regulation of Endogenous Antioxidants and Feeding Behavior in Phenylpropanolamine-Treated Rats. 2011, PMID: 21989786. DOI 10.1007/s00204-011-0761-7

2011/10

Archives Toxicology, (IF:4.04, Rank:9.63 %)

Kuo DY, Chen PN, Yang SF, Chu SC, Chen CH, Kuo MS, Yu CH, Hsieh YS*. Role of Reactive Oxygen Species-related Enzymes in Neuropeptide Y and proopiomelanocortin-
mediated Appetite Control: A Study Using Atypical Protein Kinase C Knockdown. 15:2147-59, 2011.

2011/04

Antioxidants & Redox Signalings
(IF:8.209, Rank:4.76 %)

Kuo DY, Yang SF, Chu SC, Chen CH, Chen PN, Hsieh YS*. The effect of protein kinase C-delta knockdown on anti-free radical enzyme and neuropeptide Y gene expression in phenylpropanolamine-treated rats. J. Neurochem. 114: 1217-1230, 2010.

2010/09

Journal of Neurochemistry
(IF:4.45, Rank:15 %)

Hsieh YS, Yang SF, Chen PN, Chu SC, Chen CH, Kuo DY*. Knocking down the transcript of protein kinase C-lambda modulates hypothalamic glutathione peroxidase, melanocortin receptor and neuropeptide Y gene expression in amphetamine-treated rats. J. Psychopharm. 25, 982-994, 2011

2010/06

Journal of Psychopharmcology
(IF:4.05, Rank:12 %)

Ho ML, Chen PN, Chu SC, Kuo DY, Kuo WH, Chen JY, Hsieh YS. Peonidin 3-glucoside inhibits lung cancer metastasis by downregulation of proteinases activities and MAPK pathway. Nutr Cancer. 62:505-16, 2010.

2010/05

Nutritional Cancer

Kuo DY, Yang SF, Chu SC, Chen CH, Hsieh YS *.Amphetamine-evoked changes of oxidative stress and neuropeptide Y gene expression in hypothalamus: regulation by the protein kinase C-delta signaling. Chem-Bio Int, 180:193-201, 2009

2009/04

Chemico-Biolofical Interaction
(IF:3.077, Rank:24 %)

Kuo DY*, Yang SF, Chen CH, Hsieh YS. Roles of protein kinase C-alpha isozyme in the regulation of oxidative stress and neuropeptide Y gene expression in phenylpropanolamine-mediated appetite suppression. 108:1495-1506, 2009.

2009/04

Journal of Neurochemistry
(IF:4.45, Rank:15 %)

Chen KS, Hsiao YC, Kuo DY, Chou MC, Chu SC, Hsieh YS, Lin TH.Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells. 33: 297-307, 2009.

2009/03

Leuk Res.

Hsieh YS, Yang SF, Chu SC, Kuo DY*. Interrupting activator protein-1 signaling in conscious rats can modify neuropeptide Y gene expression and feeding behavior of phenylpropanolamine. 104:50-61, 2008.

2008/02

Journal of Neurochemistry
(IF:4.45, Rank:15 %)

Hsieh YS, Yang SF, Chu SC, Ho YJ, Kuo CS, Kuo DY*. Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. 105:1438-1449, 2008.

2008/03

Journal of Neurochemistry
(IF:4.45, Rank:15 %)

Goel S, Goldberg GL, Kuo DY, Muggia F, Arezzo J, Mani S. Novel neurosensory testing in cancer patients treated with the epothilone B analog, ixabepilone. 19:2048-52, 2008.

2008/03

Ann Oncol.

Chen KS, Wang PH, Yang SF, Lin DB, Lin YJ, Kuo DY, Lin LY, Wu MT, Lin CW, Lee S, Chou MC, Tsai HT, Hsieh YS. Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease. 46:1609-16, 2008.

2008/03

Clin Chem Lab Med.

Hsieh YS, Yang SF, Chu SC, Kuo DY*. Transcript of protein kinase A knock down modulates feeding behavior and neuropeptide Y gene expression in phenylpropanolamine-treated rats. 31(2): 306-14.

2007/06

Physiological Genomics
(IF:3.493, Rank:32%)

Hsieh YS, Yang SF, Chiou HL, Kuo DY*. Roles of central catecholamine and hypothalamic neuropeptide Y genome in the development of tolerance to phenylpropanolamine-mediated appetite suppression. 121(5): 933-940, 2007.

2007/05

Behavioral Neuroscience
(IF:2.883, Rank:26.6%)

Hsieh YS, Yang SF, Kuo DY*. Intracerebral administration of protein kinase A (PKA) or c-AMP response element binding protein (CREB) antisense oligonucleiotide can modulate amphetamine-mediated appetite suppression in free-moving rats. 292: 123-131, 2007.

2007/01

American Journal of Physiology-Endoc. Met.
(IF:4.138, Rank:14.1%)

Kuo DY*. Hypothalamic neuropeptide Y (NPY) and the attenuation of hyperphagia in streptozotocin diabetic rats treated with dopamine D1/D2 agonists. 148: 640-647, 2006.

2006/08

British Journal of Pharmacology
(IF:5.204, Rank:8.01%)

Hsieh YS, Yang SF, Chiou HL, Kuo DY*. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression. 212: 99-109, 2006.

2006/04

Toxicology and Applied Pharmacology
(IF:4.722, Rank:11.5%)

Hsieh YS, Yang SF, Chiou HL, Kuo DY*. Transcriptional involvement of protein kinase C-alpha isozyme in amphetamine-mediated appetite suppression. 22: 715-723, 2005.

2005/10

European Journal of Neuroscience
(IF:2.949, Rank:24%)

HsiehYS, Yang SF, Kuo DY*. Amphetamine, an appetite suppressant, decreases neuropeptide Y immunoreactivity in rat hypothalamic paraventriculum. 127:169-176, 2005.

2005/04

Regulatory Peptides

Kuo DY*. Involvement of hypothalamic neuropeptide Y in regulating the amphetamine-induced appetite suppression in streptozotocin diabetic rats. 127:19-26, 2005.

2005/04

Regulatory Peptides

Hsieh YS, Hsu JD, Yang SF, Kuo DY*. Immunohistochemical and genomic evidence for the involvement of hypothalamic neuropeptide Y in phenylpropranolamine-mediated appetite suppression. 25: 2155-2161, 2004.

2004/12

Peptides

Kuo DY*. Further evidence for the mediation of both subtypes of dopamine D1/D2 receptors and cerebral neuropeptide Y (NPY) in amphetamine-induced appetite suppression. 147: 149-155, 2003.

2003/11

Behavioral Brain Research

Kuo DY, Goldberg GL. Screening of cervical cancer: where do we go from here? 21:157-61.

2003/11

Cancer Invest.

Cheng JT, Kuo DY*. Both a1-adrenergic and D1-dopaminergic neurotransmissions are involvedin phenylpropanolamine-mediated feeding suppression in mice. 347: 136-138, 2003.

2003/08

Neuroscience Letters

Kuo DY, Inui A, Cheng JT. Effect of repeated treatment of amphetamine on the change of feeding response in NPY overexpressing mice. 329: 359-361, 2002.

2002/10

Neuroscience Letters

Slomovitz BM, Soslow RA, Chang RC, Golub R, Kuo DY.  Serous adenocarcinoma of the inguinal region arising from endometriosis followed by a successful pregnancy. 87:152-4.

2002/08

Gynecol Oncol.

Kuo DY, Cheng JT. Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine. 44: 63-69, 2002.

2002/06

Neuroscience Research

Kuo DY*. Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level. 9: 126-132, 2002.

2002/01

Journal of Biomedical Science

Ting H, Liao JM, Lin CF, Chiang PY, Chang CC, Kuo DY, Lin TB. Pressor effect on blood pressure and renal nerve activity elicited by electroacupuncture in intact and acute hemorrhage rats. 327: 5-8, 2002.

2002/01

Neurosci. Lett.

Kuo DY; Hsu CT; Cheng JT. Role of hypothalamic neuropeptide Y (NPY) in the change of feeding behavior induced by repeated treatment of amphetamine. 70: 243-251, 2001.

2001/09

Life Science

ChenTY, Duh SL, Huang CC, Lin TB, Kuo DY*. Evidence for the involvement of dopamine D1 and D2 receptors in mediating the decrease of food intake during repeated treatment with amphetamine. 8: 462-466, 2001.

2001/08

Journal of Biomedical Science

Parikh SK, Ravi A, Kuo DY, Nori D. Bullous pemphigoid masquerading as acute radiation dermatitis: case report. 22:322-4.

2001/06

Eur J Gynaecol Oncol.

Timmins PF, Kuo DY, Anderson PS, Fields AL, Whitney KD, Goldberg GL. Ovarian carcinoid: management of primary and recurrent tumors. 76:112-4.

2001/08

Gynecol Oncol.

Kuo DY*, Lin TB, Huang CC, Duh SL, Liao JM, Cheng JT. Nicotine-induced hyperlocomotion is not modified by estrous cycle, ovariectomy and estradiol replacement at physiological level. 42: 83-88.

1999/06

Chinese J. Physiol.

Cass I, Kuo DY, Fields AL, Runowicz CD, Goldberg GL. Profound thrombocytopenia in previously treated patients with recurrent ovarian carcinoma receiving topotecan. 69:175-8.

1998/06

Gynecol Oncol.

Kuo DY*, Liu CN, Tsay JC, Chang CL, Cheng JT. Effects of nicotine on spontaneous and amphetamine-induced motor behaviors: the differences between nicotine tolerant and nontolerant rats. 41: 93-99.

1998/06

Chinese J. Physiol.

Kuo DY, Jones J, Fields AL, Runowicz CD, Goldberg GL. Endometrioid adenocarcinoma of the ovary and long-term tamoxifen therapy: a coincidence or a cause for concern? 18:457-60.

1997/06

Eur J Gynaecol Oncol.

Kavallaris M, Kuo DY, Burkhart CA, Regl DL, Norris MD, Haber M, Horwitz SB. Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes. 100:1282-93.

1997/05

J Clin Invest.

Kuo DY*, Chang CL, Liu JY. The effect of nicotine on motor activities induced by amphetamine in rats. 7: 13-22.

1996/06

Chung Shan Medical J.

Kuo DY, Mallick S, Shen HJ, DeVictoria C, Jones J, Fields AL, Goldberg GL, Runowicz CD, Horwitz SB. Analysis of MDR1 expression in normal and malignant endometrium by reverse transcription-polymerase chain reaction and immunohistochemistry. 2:1981-92, 1996.

1996/04

Clin Cancer Res.

Kuo DY, Runowicz CD. Gynaecologic effects of tamoxifen. 12:87-94.

1995/06

Med Oncol.

Smith HO, Anderson PS, Kuo DY, Goldberg GL, DeVictoria CL, Boocock CA, Jones JG, Runowicz CD, Stanley ER, Pollard JW.The role of colony-stimulating factor 1 and its receptor in the etiopathogenesis of endometrial adenocarcinoma. 1:313-25.

1995/06

Clin Cancer Res.

Kuo DY, Smith HO, Runowicz CD, Goldberg GL. Cecal cancer in a teenager presenting with a pelvic mass: a case report and review of the literature. 55:149-51.

1994/06

Gynecol Oncol.